{"created":"2023-06-20T16:34:20.363119+00:00","id":3512,"links":{},"metadata":{"_buckets":{"deposit":"2d26efad-086e-4664-9c6a-6216ee365456"},"_deposit":{"created_by":3,"id":"3512","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3512"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003512","sets":["14:2667:2675:2679:2680","21:2669:2677:2681:2682"]},"author_link":["3387"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanism of anti—HIV-1 activity mediated by Rac2"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): サイトカイン産生制御においてRac2が関与する細胞内情報伝達経路を特定した。また、その産生パターンからHIV-1感染抵抗性の分子機序として、Rac2による炎症性サイトカイン発現制御機構の関与が示唆された。Nefと同様にオートファジー制御因子として働くウイルスタンパク質を同定した。さらに、Rac2はウイルスタンパク質との相互作用を介してオートファジーに影響を与え、結果としてウイルス増殖の制御に関与しうることが示唆された。         研究成果の概要(英文): We identified a new function of human Rac2. Rac2 negatively or positively regulates several cytokines production at transcriptional level. The transcriptional regulation by Rac2 involves specific molecules acting in cellular signal transduction pathway. The regulation of inflammatory cytokines would be the one of  mechanisms by which Rac2 mediates the anti-HIV-1 activity. We found that Rac2 associates with viralproteins which can control autophagy. These interactions implied that Rac2 suppresses HIV-1 replication through modification of celluar autophagy activity controlled by proteins.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号: 34419;   研究種目：若手研究(B);   研究期間：2011～2012;   課題番号：23790510;   研究分野：分子ウイルス学;    科研費の分科・細目：基礎医学・ウイルス学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30344500.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAKATA, YOSHIYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"博多,  義之"},{"creatorName":"ハカタ, ヨシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3387","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30344500","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_23790510seika.pdf","filesize":[{"value":"770.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23790510seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3512/files/KAKEN_23790510seika.pdf"},"version_id":"1ffb46b6-a26f-40d2-a4b6-c108cf1d0e86"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"rac2","subitem_subject_scheme":"Other"},{"subitem_subject":"感染抵抗性因子","subitem_subject_scheme":"Other"},{"subitem_subject":"感染制御","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HIV-1感染抵抗性因子Rac2によるウイルス増殖制御様式の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HIV-1感染抵抗性因子Rac2によるウイルス増殖制御様式の解明"}]},"item_type_id":"8","owner":"3","path":["2680","2682"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-19"},"publish_date":"2013-07-19","publish_status":"0","recid":"3512","relation_version_is_last":true,"title":["HIV-1感染抵抗性因子Rac2によるウイルス増殖制御様式の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:33:03.305890+00:00"}