{"created":"2023-06-20T16:34:20.277190+00:00","id":3510,"links":{},"metadata":{"_buckets":{"deposit":"043c45fa-d1bc-4f50-8c09-1687aa9d916f"},"_deposit":{"created_by":3,"id":"3510","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3510"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003510","sets":["14:2667:2675:2679:2680","21:2669:2677:2681:2682"]},"author_link":["3167"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では肝修復過程におけるu-PA/プラスミン系によるマクロファージの機能制御機構を検討した。その結果、肝修復過程においてu-PA/プラスミン系が障害部位へマクロファージを集積させ、肝修復に必須であることが明らかになった。さらに、u-PA/プラスミン系は肝障害部位周囲の微小環境中のサイトカイン発現を介して集積したマクロファージにおいて多様な表現型と細胞極性を誘導し、壊死組織の貪食に寄与することが明らかになった。          研究成果の概要（英文）：We investigated novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair. Our study indicates that u-PA/plasmin system is essential for liver repair through triggering macrophage accumulation at the border region of damaged site. Moreover, u-PA/plasmin system mediates the induction of phenotypic heterogeneity, cell polarity, and phagocytosis of necrotic tissue in the accumulated macrophages by its influence of the surrounding microenvironment at the edge of damaged tissue during liver repair.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号: 34419;   研究種目：若手研究(B);   研究期間：2011～2012;   課題番号：23790260;   研究分野：医歯薬学;    科研費の分科・細目：基礎医学・生理学一般","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/70388510.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWAO, NAOYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河尾,  直之"},{"creatorName":"カワノ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3167","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70388510","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_23790260seika.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23790260seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3510/files/KAKEN_23790260seika.pdf"},"version_id":"0091464d-f99a-45b1-9795-5b88c0d7cafc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝修復","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"組織線溶系","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝修復過程におけるu-ＰＡ／プラスミン系による新規なマクロファージ機能制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝修復過程におけるu-ＰＡ／プラスミン系による新規なマクロファージ機能制御機構"}]},"item_type_id":"8","owner":"3","path":["2680","2682"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-19"},"publish_date":"2013-07-19","publish_status":"0","recid":"3510","relation_version_is_last":true,"title":["肝修復過程におけるu-ＰＡ／プラスミン系による新規なマクロファージ機能制御機構"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:33:06.738453+00:00"}