{"created":"2023-06-20T16:34:17.612447+00:00","id":3449,"links":{},"metadata":{"_buckets":{"deposit":"7c8767af-6988-4f6a-afd1-661810f7cb17"},"_deposit":{"created_by":3,"id":"3449","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3449"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003449","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["4078","4076","4077","4080","4079"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of automated blood sampling in uL order, metabolite analysis, and an algorithm for noise reduction for quantitative PET molecular imaging using PET"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 本研究は, マウスを用いた定量PET撮像において必要となる, 自動採血手法, 代謝物分析法, PETデータの雑音低減法の開発を目的とした. 採血については, マウスの生理状態への影響が無い量である数μLでの自動採血, 血漿分離, 体積及び放射能測定を行うシステムを開発した. またこの下で, 代謝物分析の実施が可能であることを示した. 更に, 統計モデルを導入することで, 小動物由来のPETデータ特有の劣悪な雑音特性の改善が可能なアルゴリズムを提案した. 本成果により, 人や大型動物に対して既に確立している定量PET撮像法をマウスに対しても適用可能となったことから, 今後の医学生理学研究への適用が期待できる.           研究成果の概要（英文): This project aimed at developing methods for blood sampling, metabolite analysis, and noise deduction for quantitative functional molecular imaging using PET and mice. The blood sampling system can be operated automatically, and it can separate the plasma and measure the volume and an amount of radioactivity using a few micro-litter of sampled blood that does not affect mice physiological condition. Direct metabolite analysis is also archived with the sampling system. And, a statistical model for noise in measured data can reduce the noise. These achievements can be applied mice to fully quantitative PET functional imaging to mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24591805;   研究分野：PET定量解析;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60205002.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90247643.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60282688.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/50228475.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KIMURA, Yuichi"},{"subitem_text_language":"en","subitem_text_value":"TOYAMA, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"HONTANI, Hidekata"},{"subitem_text_language":"en","subitem_text_value":"HATANO, Kentaro"},{"subitem_text_language":"en","subitem_text_value":"YAMADA, Takashi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"藤田保健衛生大学医学部; 教授"},{"subitem_text_value":"名古屋工業大学情報工学部; 教授"},{"subitem_text_value":"国立長寿医療研究センター認知症先進医療開発センター; 室長"},{"subitem_text_value":"中部大学応用生物学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Fujita Health University"},{"subitem_text_value":"Nagoya Institute of Technology"},{"subitem_text_value":"National Center for Geriatrics and Gerontology"},{"subitem_text_value":"Chubu University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村,  裕一"},{"creatorName":"キムラ, ユウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"外山,  宏"},{"creatorName":"トヤマ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本谷,  秀堅"},{"creatorName":"ホンタニ, ヒデカタ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"旗野,  健太郎"},{"creatorName":"ハタノ, ケンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田,  貴史"},{"creatorName":"ヤマダ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_24591805seika.pdf","filesize":[{"value":"731.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_24591805seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3449/files/KAKEN_24591805seika.pdf"},"version_id":"13fbf2fb-1cfd-4062-969b-7ea7e025a316"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"分子イメージング","subitem_subject_scheme":"Other"},{"subitem_subject":"PET","subitem_subject_scheme":"Other"},{"subitem_subject":"核医学","subitem_subject_scheme":"Other"},{"subitem_subject":"動物実験","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウスPET定量分子イメージングへのμL自動採血・代謝物分析・雑音低減法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスPET定量分子イメージングへのμL自動採血・代謝物分析・雑音低減法の開発"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-30"},"publish_date":"2015-10-30","publish_status":"0","recid":"3449","relation_version_is_last":true,"title":["マウスPET定量分子イメージングへのμL自動採血・代謝物分析・雑音低減法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:35:14.632068+00:00"}