{"created":"2023-06-20T16:34:17.109213+00:00","id":3437,"links":{},"metadata":{"_buckets":{"deposit":"f999b118-6668-4589-b504-1477d1c01d20"},"_deposit":{"created_by":3,"id":"3437","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3437"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003437","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["4061"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Approach from muscle to bone and cartilage regeneration and development of the treatment of diseases"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 本研究では筋組織が骨・軟骨再生を誘導する機序を明らかにすることを目的として, 筋組織での異所性骨化を破骨細胞形成の観点から検討した. 筋組織では皮下組織と比較して, 筋芽細胞とBMP-2の移植による異所性骨化が増加し, また破骨細胞の増加が見られた. さらに, 進行性骨化性線維異形成症の原因遺伝子である活性型BMP受容体を強制発現させた筋芽細胞はin vivoおよびin vitroにおいてTGF-βの発現を増加させ破骨細胞分化を促進することが明らかとなった. 以上より, 筋芽細胞が破骨細胞形成を促進して骨・軟骨再生を誘導することが示唆された.                      研究成果の概要（英文): We investigated the role of osteoclasts during heterotopic bone formation in muscle tissue. The implantation of myoblasts with BMP-2 induced robust heterotopic ossification with an increase in the formation of osteoclasts in the muscle tissues than subcutaneous tissues. Moreover, the causal mutation transfection of fibrodysplasia ossification progressive in myoblasts enhanced the formation of osteoclasts through TGF-β in vivo and in vitro. This study demonstrated that the causal mutation transfection of fibrodysplasia ossification progressive in myoblasts enhances bone and cartilage regeneration through formation of osteoclasts from its precursor in muscle tissues.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2013～2014;   課題番号：25861347;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30500821.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YANO, Masato"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢野,  昌人"},{"creatorName":"ヤノ, マサト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4061","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30500821","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_25861347seika.pdf","filesize":[{"value":"868.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_25861347seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3437/files/KAKEN_25861347seika.pdf"},"version_id":"8ccea71f-a21c-44f7-8a90-eaa7ce082338"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"筋芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"異所性骨化","subitem_subject_scheme":"Other"},{"subitem_subject":"進行性骨化性線維異形成症","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨・軟骨再生への筋からのアプローチと疾患治療への展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨・軟骨再生への筋からのアプローチと疾患治療への展開"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-23"},"publish_date":"2015-10-23","publish_status":"0","recid":"3437","relation_version_is_last":true,"title":["骨・軟骨再生への筋からのアプローチと疾患治療への展開"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:35:39.009452+00:00"}