{"created":"2023-06-20T16:34:16.928825+00:00","id":3433,"links":{},"metadata":{"_buckets":{"deposit":"fc028f3a-db83-4cbf-b67f-2abd2f80e4cc"},"_deposit":{"created_by":3,"id":"3433","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3433"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003433","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["4058","4057","4059"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of acquired resistance mechanisms to next-generation kinase inhibitors in lung cancers with EGFR mutation."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): EGFRキナーゼ阻害剤はEGFR変異肺がん治療のkey drugであるが, 獲得耐性の出現は必発である. 獲得耐性後の治療戦略を考える上で, (1)獲得耐性後に殺細胞性抗癌剤の感受性は変化するか, (2)獲得耐性の分子機序は既知のもの以外にどのような分子異常があるか, (3)次世代のEGFRキナーゼ阻害剤に対する獲得耐性機序としてはどのような分子異常が生じ得るか, は重要な課題である. 本研究ではこれらの課題について, 主にin vitro の系を用いて検討をおこなった.                      研究成果の概要（英文): EGFR kinase inhibitors are the key drugs in the treatment of lung cancer patients with EGFR activating mutations. However, emergence of acquired resistance to these drugs is almost inevitable. There are several unanswered issues to establish best treatment strategies after acquisition of resistance to EGFR kinase inhibitors. These include, (1) if chemosensitivity alters after acquisition of resistance, (2) novel resistance mechanisms other than T790M mutation. MET amplification, ERBB2 amplification, etc, and (3) molecular mechanisms that confer acquired resistance to next-generation EGFR kinase inhibitors. In this work, we analyzed these points, mainly using in vitro models.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2013～2014;   課題番号：25830119;   研究分野：腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30631593.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SUDA, Kenichi"},{"subitem_text_language":"en","subitem_text_value":"MIZUUCHI, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"SATO, Katsuaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"須田,  健一"},{"creatorName":"スダ, ケンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"水内,  寛"},{"creatorName":"ミズウチ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤,  克明"},{"creatorName":"サトウ, カツアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_25830119seika.pdf","filesize":[{"value":"231.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_25830119seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3433/files/KAKEN_25830119seika.pdf"},"version_id":"4fa9462c-bad6-466b-b44a-1b687bf52588"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"分子標的薬","subitem_subject_scheme":"Other"},{"subitem_subject":"肺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"EGFR変異","subitem_subject_scheme":"Other"},{"subitem_subject":"個別化治療","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"EGFR肺癌における新規キナーゼ阻害剤に対する耐性の分子機序とその克服","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EGFR肺癌における新規キナーゼ阻害剤に対する耐性の分子機序とその克服"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-23"},"publish_date":"2015-10-23","publish_status":"0","recid":"3433","relation_version_is_last":true,"title":["EGFR肺癌における新規キナーゼ阻害剤に対する耐性の分子機序とその克服"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:35:45.740645+00:00"}