{"created":"2023-06-20T16:34:16.569544+00:00","id":3425,"links":{},"metadata":{"_buckets":{"deposit":"36810a41-0558-4a06-ac02-d4a5904a8ed8"},"_deposit":{"created_by":3,"id":"3425","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3425"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003425","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["4033","4031","4032"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"(-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014 )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): エピガロカテキンガレート（EGCG)は緑茶に含まれる抗酸化作用を有する物質である. EGCG飲水による脳外傷後の神経幹細胞の出現・分化について調べた. EGCGは0.1%水溶液としてラットに与えた(EGCG群). 対照群は通常水を用いた(water群). EGCG群ではwater群に比較し神経細胞数及び神経幹細胞数が多数であった. water群では神経細胞や神経幹細胞にアポトーシスを認めたがEGCG群ではほとんど認めなかった. EGCG群での神経幹細胞は神経細胞, アストロサイト, オリゴデンドロサイトへの分化を認めた. EGCG飲水は脳外傷後の神経細胞・神経幹細胞の生存・維持に関与していることが示された.           研究成果の概要（英文): A major component of green tea is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. we investigated the effect of EGCG on neural stem cell (NSC) proliferation following traumatic brain injury (TBI). Male Wistar rats that had access to normal drinking water, or water containing 0.1% (w/v) EGCG, ad libitum. Immunohistochemistry revealed that the number of nestin-positive cells after TBI in the EGCG group increased significantly. The number of single-stranded DNA (ssDNA)-positive cells after TBI significantly decreased in the EGCG group. Almost all ssDNA-positive cells in the water group co-localized with NeuN and nestin-staining. Spheres could only be isolated in the water group at 3 days. In the EGCG group, spheres could be isolated at all days following TBI. Spheres differentiated into neurons and glia. These results indicate that EGCG inhibits degradation of NSCs, which have the potential to differentiate into neurons and glia following TBI.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24501009;   研究分野：神経病理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/70162443.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40330245.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SATO, Takao"},{"subitem_text_language":"en","subitem_text_value":"Itoh, TATSUKI"},{"subitem_text_language":"en","subitem_text_value":"Inoue, TAKAO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University Hospital, Faculty of Medicine"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤,  隆夫"},{"creatorName":"サトウ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤,  龍生"},{"creatorName":"イトウ, タツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上,  敬夫"},{"creatorName":"イノウエ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24501009seika.pdf","filesize":[{"value":"694.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24501009seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3425/files/24501009seika.pdf"},"version_id":"81134740-4242-4a19-937c-b37f7d1ab4db"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳外傷","subitem_subject_scheme":"Other"},{"subitem_subject":"神経再生","subitem_subject_scheme":"Other"},{"subitem_subject":"カテキン","subitem_subject_scheme":"Other"},{"subitem_subject":"緑茶飲料","subitem_subject_scheme":"Other"},{"subitem_subject":"神経幹細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"緑茶が及ぼす脳外傷局所に出現する神経幹細胞の成熟, 分化への影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"緑茶が及ぼす脳外傷局所に出現する神経幹細胞の成熟, 分化への影響に関する研究"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-09"},"publish_date":"2015-10-09","publish_status":"0","recid":"3425","relation_version_is_last":true,"title":["緑茶が及ぼす脳外傷局所に出現する神経幹細胞の成熟, 分化への影響に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:36:02.867196+00:00"}