{"created":"2023-06-20T16:34:16.209244+00:00","id":3417,"links":{},"metadata":{"_buckets":{"deposit":"4fc5d73b-786d-4fa4-82b7-074400b41878"},"_deposit":{"created_by":3,"id":"3417","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3417"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003417","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["3706"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Enhanced nerve-mast cell interaction mediated by cell adhesion molecule 1 in stress-related diseases"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014 )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): ハプテン誘導型アトピー性皮膚炎マウスモデルにおける神経--マスト細胞間相互作用の実態とIgCAM型接着分子CADM1の役割を解析した. 病変内のマスト細胞数は健常対照の約5倍で, 病変内の各マスト細胞におけるCADM1 mRNA発現は健常対照の約3倍であった. マスト細胞と後根神経節細胞との共生培養系において, マスト細胞と神経突起との接着力, 及び神経脱分極に応答するマスト細胞の割合は, マスト細胞におけるCADM1の発現レベルと相関した. アトピー性皮膚炎ではマスト細胞におけるCADM1の発現上昇の結果神経--マスト細胞相互作用が増強しているため, 精神的なストレスによって症状が増悪する可能性が示唆された.           研究成果の概要（英文): Neuroimmunological disorders are involved in the pathogenesis of atopic dermatitis (AD), partly through enhanced sensory nerve-skin mast cell interaction. Cell adhesion molecule 1 (CADM1) is known to mediate nerve-mast cell interaction. In a hapten-induce AD mouse model, AD-like lesional mast cells expressed three-fold more CADM1 transcripts than non-lesional mast cells. In nerve-mast cell coculture, CADM1 overexpression in IC2 mast cells strengthened dorsal root ganglion neurite-IC2 cell adhesion and doubled the population of IC2 cells responding to nerve activation. Increased expression of CADM1 in mast cells appeared to be a cause of enhanced sensory nerve-mast cell interaction in a hapten-induced AD mouse model, and might be involved in stress-induced deterioration of human AD.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24590492;   研究分野：実験病理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/80273647.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ITO, Akihiko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤,  彰彦"},{"creatorName":"イトウ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3706","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80273647","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24590492seika.pdf","filesize":[{"value":"197.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24590492seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3417/files/24590492seika.pdf"},"version_id":"0e97bc85-25bd-4f17-bc95-7ad153a1a5ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"接着分子","subitem_subject_scheme":"Other"},{"subitem_subject":"神経--免疫相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"アトピー性皮膚炎","subitem_subject_scheme":"Other"},{"subitem_subject":"脱顆粒","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞間接着力","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレス関連疾患における神経--マスト細胞相互作用の増強 : 接着分子ＣＡＤＭ1の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレス関連疾患における神経--マスト細胞相互作用の増強 : 接着分子ＣＡＤＭ1の関与"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-09"},"publish_date":"2015-10-09","publish_status":"0","recid":"3417","relation_version_is_last":true,"title":["ストレス関連疾患における神経--マスト細胞相互作用の増強 : 接着分子ＣＡＤＭ1の関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:36:21.268563+00:00"}