{"created":"2023-06-20T16:34:16.164592+00:00","id":3416,"links":{},"metadata":{"_buckets":{"deposit":"425bc289-c360-479d-9cb1-cbe5d26baa7e"},"_deposit":{"created_by":3,"id":"3416","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3416"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003416","sets":["14:2667:2668:2987","21:2669:2670:2988"]},"author_link":["4008","4007","4006","4005"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Basic scientific research for formulating drugs for treatment of hypertension"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014 )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): High mobility group box1(HMGB1)は, 免疫応答に大きく関与している. 申請者らは, HMGB1が脳梗塞, アテローム性動脈硬化症などの原因因子で, 抗HMGB1抗体でこれらを抑制できることを報告した. HMGB1の高血圧症の病態生理への関与はまだ明らかではないので, 脳卒中易発症高血圧症自然発症ラット (SHRSP)を用いて検討してきた. 血管内皮細胞障害が高血圧症の原因であるが, HMGB1の血管内皮細胞障害は確認出来なかったが, 好中球活性化が血管内皮細胞障害を誘導する機序を解明することが出来た. 好中球活性化制御因子を特定したので, 高血圧症新規治療薬の開発に向けた研究を継続する.            研究成果の概要（英文): Recent studies have shown that high mobility group box1 (HMGB1) plays roles in immune response. We have reported that anti-HMGB1 Ab inhibited the progression of brain infarction and atherosclerosis. However, little is known whether HMGB1 induces the vascular injury, we investigated the involvement of HMGB1 in the endothelial dysfunction and injury using stroke-prone spontaneously hypertensive rats (SHRSP). It is well known that the endothelial dysfunction and injury induces hypertension. Although we could not prove the effect of HMGB1 on the endothelial dysfunction and injury, during this project, we found the mechanism of neutrophil-induced endothelial dysfunction and injury. Moreover, we found a mediator which inhibited the activation of neutrophil. Therefore, we continue the promotion of basic scientific research for formulating drugs for treatment of hypertension.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24590337;   研究分野：薬理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60335627.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60122082.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/50135943.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40432637.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TAKAHASHI, Hideo"},{"subitem_text_language":"en","subitem_text_value":"NIWA, Atsuko"},{"subitem_text_language":"en","subitem_text_value":"NISHIBORI, Masahiro"},{"subitem_text_language":"en","subitem_text_value":"RYU, Katsuyaku"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"岡山大学医歯薬総合研究科; 教授"},{"subitem_text_value":"岡山大学医歯薬総合研究科; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Okayama University"},{"subitem_text_value":"Okayama University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋,  英夫"},{"creatorName":"タカハシ, ヒデオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4005","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40432637","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"丹羽,  淳子"},{"creatorName":"ニワ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西堀,  正洋"},{"creatorName":"ニシボリ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"劉,  克約"},{"creatorName":"リュウ, カツヤク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4008","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24590337seika.pdf","filesize":[{"value":"184.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24590337seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3416/files/24590337seika.pdf"},"version_id":"970cc9fd-fe37-4820-81a3-756e96ad273c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"High mobility group box1","subitem_subject_scheme":"Other"},{"subitem_subject":"SHR","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧症","subitem_subject_scheme":"Other"},{"subitem_subject":"抗HMGB1抗体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規作用機序をもつ高血圧症治療薬開発の基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規作用機序をもつ高血圧症治療薬開発の基礎的研究"}]},"item_type_id":"8","owner":"3","path":["2987","2988"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-09"},"publish_date":"2015-10-09","publish_status":"0","recid":"3416","relation_version_is_last":true,"title":["新規作用機序をもつ高血圧症治療薬開発の基礎的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:36:23.522744+00:00"}