{"created":"2023-06-20T16:34:09.978714+00:00","id":3271,"links":{},"metadata":{"_buckets":{"deposit":"f2d1f2ea-895b-4601-b7af-64b982a8ae32"},"_deposit":{"created_by":3,"id":"3271","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3271"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003271","sets":["14:2667:2675:2676","21:2669:2677:2678"]},"author_link":["3752"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulatory mechanism of the cell integrity signaling mediated by mRNA—binding proteins"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2012. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 細胞形態や細胞周期を制御する〈細胞統御〉シグナルとmRNA結合タンパク質の関わりを、分裂酵母モデル生物を用いて解析を行なった。mRNA結合タンパク質Nrd1を同定し、Nrd1がMyosin mRNAと結合し、安定化することにより、細胞周期調節に関わることを見出した。また、高等生物のERK相同因子Pmk1が、Nrd1を細胞周期依存的にリン酸化制御することにより、細胞運命の調節に関わることを見出した。さらに、Nrd1がリン酸化依存的にストレス穎粒に移行すること、ストレス穎粒形成はストレス応答のみならず、抗がん剤抵抗性を調節するという生理的意義を見出した。 　  　  研究成果の概要（英文）：We identified the mRNA-binding protein Nrd1 and demonstrated that Nrd1 binds to and regulates mRNA stability of the Myosin mRNA. We also showed that Pmk1 MAPK, a homologue of ERK in fission yeast regulates the RNA-binding activity of Nrd1 in a phosphorylation-dependent manner. Moreover, Nrd1 translocated to the stress granules in a MAPK-mediated phosphorylation-dependent manner, thereby regulates stress tolerance in fission yeast.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"機関番号：34419;    研究種目：新学術領域研究(研究領域提案型);   研究期間：2008～2012;   課題番号：20112008;    研究分野：多様性と非対称性を獲得するRNAプログラム","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90294206.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SUGIURA, REIKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉浦,  麗子"},{"creatorName":"スギウラ, レイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3752","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90294206","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20112008seika.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20112008seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3271/files/KAKEN_20112008seika.pdf"},"version_id":"3e03e5e7-6b93-4483-86fc-cbe6aa0f5d19"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MAPキナーゼシグナル","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA結合タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA顆粒","subitem_subject_scheme":"Other"},{"subitem_subject":"mRNA安定性","subitem_subject_scheme":"Other"},{"subitem_subject":"分子遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"分裂酵母モデル生物","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内シグナル伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"mRNA結合タンパク質による細胞統御のメカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"mRNA結合タンパク質による細胞統御のメカニズム"}]},"item_type_id":"8","owner":"3","path":["2676","2678"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-12"},"publish_date":"2013-07-12","publish_status":"0","recid":"3271","relation_version_is_last":true,"title":["mRNA結合タンパク質による細胞統御のメカニズム"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:41:10.764361+00:00"}