{"created":"2023-06-20T16:34:09.339487+00:00","id":3256,"links":{},"metadata":{"_buckets":{"deposit":"e58fd9d2-4db7-4db8-a34b-8ce3c1d7dcfb"},"_deposit":{"created_by":3,"id":"3256","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3256"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003256","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3301"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Identification of tumor antigen derived peptides having the potential to promise candidates for cancer vaccine therapy from prostate cancer patients"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：前立腺癌患者より末梢血を採取し、末梢血単核球細胞を遠心分離とHLA-A をanti-HLA-A11 ,-A31 ,-A33 mAb を使用しフローサイトメトリーにて同定しHLA-A11,-A31,-A33 陽性のものを対象とした。3 種類の前立腺癌関連抗原のクラスⅠ拘束性ペプチドを1抗原3～5種類合成しCTL assay にてEZHp_<733-741>ペプチドにて特異的CTLの誘導を確認し癌ワクチン療法に応用できるペプチド候補として予測される。            研究成果の概要（英文）：Peripheral blood mononuclear cells (PBMCs) were obtained from prostate cancer patients. The PBMCs were prepared by Ficoll-Conray density gradient centrifugation. The expression of HLA-A11,-A31,and-A33 molecules on the PBMCs was determined by flow cytometry using these antibodies-anti-HLA-A11,-A31,-A33-and FITC-conjugated anti-mouse IgG monoclonal antibodies. 3 prostate cancer-related antigens prepared based on the binding motifs to the MHC-classⅠalleles. It is predicted as a peptide candidate that be identified induction of specific CTL with EZHp_<733-741> peptide in CTL assay, and can apply to a cancer vaccine treatment.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;  研究期間：2010～2011;   課題番号：22791505;   研究分野：医歯薬学;   科研費の分科・細目：泌尿器科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70340809.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MINAMI, TAKAFUMI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"南,  高文"},{"creatorName":"ミナミ, タカフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3301","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70340809","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22791505seika.pdf","filesize":[{"value":"81.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22791505seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3256/files/KAKEN_22791505seika.pdf"},"version_id":"ac2f7de0-90d6-467d-bfd7-2e10d52b7ecf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"癌ワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-A3 supertype alleles","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"前立腺癌患者に対する癌ワクチン療法に応用できる腫瘍関連抗原由来ペプチドの同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前立腺癌患者に対する癌ワクチン療法に応用できる腫瘍関連抗原由来ペプチドの同定"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-13"},"publish_date":"2012-11-13","publish_status":"0","recid":"3256","relation_version_is_last":true,"title":["前立腺癌患者に対する癌ワクチン療法に応用できる腫瘍関連抗原由来ペプチドの同定"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:41:37.605849+00:00"}