{"created":"2023-06-20T16:34:09.255286+00:00","id":3254,"links":{},"metadata":{"_buckets":{"deposit":"b061b4f7-8407-4637-a6e9-6504e7be29ec"},"_deposit":{"created_by":3,"id":"3254","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3254"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003254","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3738"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The examination of oxidative stress and endoplasmic reticulum stress in diabetes mellitus"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：2型糖尿病の病態では、ASK-JNK 経路が酸化ストレスと小胞体ストレスの両者に深く関与する重要な経路であり、インスリン抵抗性改善のkey pathway の可能性であることが考えられた。また、このASK-JNK 経路を調節することが、2型糖尿病患者に対しての治療標的になりえる可能性があり、そのことが将来的に糖尿病性合併症の予防・進展抑制につながっていく可能性を期待している。              研究成果の概要（英文）：In diabetes, ASK-JNK pathway is  considerably involved to oxidative stress and endoplasmic reticulum stress. So, we could think that this pathway was key pathway to improve insulin resistance. Moreover, to adjust this ASK-JNK pathway it can become a therapeutic target to type 2 diabetic patients, and it expects a possibility that this intervention will lead to prevention and slowly progression of diabetic complication in the future.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;  研究期間：2010～2011;   課題番号：22790873;   研究分野：医歯薬学;   科研費の分科・細目：内科系臨床医学、代謝学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40568606.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKATANI, YOSHIHISA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中谷,  嘉寿"},{"creatorName":"ナカタニ, ヨシヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3738","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40568606","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22790873seika.pdf","filesize":[{"value":"37.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22790873seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3254/files/KAKEN_22790873seika.pdf"},"version_id":"3e801c83-26b2-4b81-a6f4-453a67d3004c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"小胞体ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"臓器障害","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖尿病における酸化ストレス、小胞体ストレスの病態解明について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病における酸化ストレス、小胞体ストレスの病態解明について"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-13"},"publish_date":"2012-11-13","publish_status":"0","recid":"3254","relation_version_is_last":true,"title":["糖尿病における酸化ストレス、小胞体ストレスの病態解明について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:41:41.316774+00:00"}