{"created":"2023-06-20T16:34:09.212689+00:00","id":3253,"links":{},"metadata":{"_buckets":{"deposit":"66649525-f7db-4797-8822-45ae4ddf8bac"},"_deposit":{"created_by":3,"id":"3253","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3253"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003253","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3737"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of liver fibrosis therapy targeting hepatic stellate cells by microRNA"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究により星細胞の活性化やコラーゲン産生に重要なマイクロRNAが数種同定された。その中でもcollagen 1A1に結合する可能性の高いmiR-29bに着目した。このマイクロRNAを星細胞で強制発現させると、I型コラーゲンの発現が抑制された。また、miR-29bは、マウス星細胞の活性化に伴い発現が低下することを明らかにした。マウス星細胞にmiR-29bを強制発現させると、I型コラーゲンの発現が抑制されるだけでなく、星細胞の活性化まで抑えられることが判明した。このため、miR-29bの標的遺伝子はcollagen 1A1だけでなく、星細胞の活性化に関与する遺伝子である可能性が示唆された。                     研究成果の概要（英文）：Some microRNAs important for activation and collagen production of stellate cells were identified. Among them, we showed that miR-29b is one of regulators of type I collagen mRNA and protein expression. Moreover, miR-29b downregulated in mouse activated stellate cells in vitro. Overexpression of miR-29b in mouse stellate cells not only decreased type I collagen mRNA and protein expression, but also inhibited stellate cell activation. We suggested that targeted genes of miR-29b were not only collagen 1A1 but stellate cell activation-related genes.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2010～2011;   課題番号：22790666;   研究分野：肝臓病学;   科研費の分科・細目：内科系臨床医学・消化器内科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70448752.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"OGAWA, TOMOHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学工学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小川,  智弘"},{"creatorName":"オガワ, トモヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3737","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70448752","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_22790666seika.pdf","filesize":[{"value":"473.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_22790666seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3253/files/KAKEN_22790666seika.pdf"},"version_id":"78dcdcb9-07a4-41a9-a39b-9c91e9793f14"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"星細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"星細胞を標的としたマイクロRNA の強制発現による線維化治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"星細胞を標的としたマイクロRNA の強制発現による線維化治療法の開発"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-13"},"publish_date":"2012-11-13","publish_status":"0","recid":"3253","relation_version_is_last":true,"title":["星細胞を標的としたマイクロRNA の強制発現による線維化治療法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:41:43.037160+00:00"}