{"created":"2023-06-20T16:34:08.832416+00:00","id":3244,"links":{},"metadata":{"_buckets":{"deposit":"cebd2194-3ea1-41d5-afd5-5cd74b514f1a"},"_deposit":{"created_by":3,"id":"3244","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3244"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003244","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3712","3714","3711","3713"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Identification and characterization of susceptibility genes for type 1 diabetes by using syntenic homology between human and mouse"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：１型糖尿病遺伝子の解析をヒトとマウスの染色体相同性を駆使して進めた結果、主効果遺伝子であるHLAとの関連にサブタイプ間で差を認めること（劇症と他のサブタイプ間で質的差異、緩徐進行と急性発症間で量的差異）、臓器特異性を決定する遺伝子としてインスリン異的転写因子MafAが胸腺でのインスリン発現量の変化を介して１型糖尿病の疾患感受性に関与することが示された。             研究成果の概要（英文）：Susceptibility genes for type 1 diabetes were studied by using syntenic homology between mouse and human. Contribution of HLA to type 1 diabetes was shown to be different among three subtypes of type 1 diabetes: qualitative difference between fulminant and other subtypes, and quantitative difference between slowly progressive and acute-onset. Functional polymorphisms of MafA, an insulin transactivator, were associated with reduced expression of insulin in the thymus and susceptibility to type 1 diabetes both in mice and humans through the reduced expression of insulin in the thymus.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2009～2011;   課題番号：21591152;   研究分野：医歯薬学;   科研費の分科・細目：内科系臨床医学・代謝学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20221062.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/80423185.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90460849.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/10449837.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, HIROSHI"},{"subitem_text_language":"en","subitem_text_value":"KAWABATA, YUMIKO"},{"subitem_text_language":"en","subitem_text_value":"NOSO, SHINSUKE"},{"subitem_text_language":"en","subitem_text_value":"BABAYA, NARU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池上,  博司"},{"creatorName":"イケガミ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川畑,  由美子"},{"creatorName":"カワバタ, ユミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"能宗,  伸輔"},{"creatorName":"ノウソウ, シンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬場谷,  成"},{"creatorName":"ババヤ, ナル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21591152seika.pdf","filesize":[{"value":"129.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21591152seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3244/files/KAKEN_21591152seika.pdf"},"version_id":"959c12ac-7275-42e2-a2c5-0ebb2dc73d24"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"１型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"劇症１型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"緩徐進行１型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒトとマウスの相同性を駆使した1型糖尿病遺伝子の同定ならびに機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトとマウスの相同性を駆使した1型糖尿病遺伝子の同定ならびに機能解析"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-13"},"publish_date":"2012-11-13","publish_status":"0","recid":"3244","relation_version_is_last":true,"title":["ヒトとマウスの相同性を駆使した1型糖尿病遺伝子の同定ならびに機能解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:42:02.417291+00:00"}