{"created":"2023-06-20T16:34:08.192754+00:00","id":3229,"links":{},"metadata":{"_buckets":{"deposit":"bc046b22-781e-4d8d-a6a2-05230734eeef"},"_deposit":{"created_by":3,"id":"3229","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3229"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003229","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3690","3691","3692"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulation of Wnt/Snail signal and MMP on head and neck cancer invasion and metastasis"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Wntシグナルおよびその下流に存在するSnailが、マトリックスメタロプロテアーゼ(MT-MMPs)の発現を誘導することによって癌細胞の浸潤・転移を促進することを、新しい簡便なinvivoモデルである鶏卵絨毛尿膜を用いたchick chorioallantoic membraneassay (CAM assay)で明らかにした。また高度の浸潤・転移能を有する癌細胞のSnail発現を抑制すると浸潤・転移は抑制されることから、Snail を標的とした阻害薬が癌の浸潤・転移を抑制する新しい治療法になる可能性が示唆された。            研究成果の概要(英文): We demonstrate that Wnt signaling and its downstream factor, Snail, induce cancer invasion and metastasis in vivo via a matrix metalloproteinase—dependent process, using a chick chorioallantoic membrane invasion assay (CAM invasion assay) . Furthermore, siRNA—specific silencing of Snail ablates the ability of cancer invasion and metastasis. Taken together, these data suggest that Snaill—targeted therapy could be effective to cancer invasion and metastasis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2009～2011;   課題番号：21592203;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・耳鼻咽喉科","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40220199.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60094554.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00326323.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YANE, KATSUNARI"},{"subitem_text_language":"en","subitem_text_value":"ONISHI, TAKEO"},{"subitem_text_language":"en","subitem_text_value":"OTA, ICHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"奈良医科大学医学部; 教授"},{"subitem_text_value":"奈良医科大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"家根,  且有"},{"creatorName":"ヤネ, カツナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3690","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00326323","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"大西,  武雄"},{"creatorName":"オオニシ, タケオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田,  一郎"},{"creatorName":"オオタ, イチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3692","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21592203seika.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21592203seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3229/files/KAKEN_21592203seika.pdf"},"version_id":"9855a1b5-6e1a-4d93-9ca4-df0c0adc7eb7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"頭頸部がん","subitem_subject_scheme":"Other"},{"subitem_subject":"浸潤","subitem_subject_scheme":"Other"},{"subitem_subject":"転移","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt","subitem_subject_scheme":"Other"},{"subitem_subject":"Snail","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"頭頸部がんの浸潤・転移に対するWnt/SnailシグナルとMMPの制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"頭頸部がんの浸潤・転移に対するWnt/SnailシグナルとMMPの制御"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-13"},"publish_date":"2012-11-13","publish_status":"0","recid":"3229","relation_version_is_last":true,"title":["頭頸部がんの浸潤・転移に対するWnt/SnailシグナルとMMPの制御"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:42:29.509510+00:00"}