{"created":"2023-06-20T16:34:07.599435+00:00","id":3215,"links":{},"metadata":{"_buckets":{"deposit":"1b0e45c6-ae0d-4798-9067-f479b533760a"},"_deposit":{"created_by":3,"id":"3215","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3215"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003215","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3664","3663"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"3","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Trichothecium roseumの生産する抗発がんプロモーター活性ならびに発がんプロモーター活性を同時にもつ二重活性のセスキテルペンであるTTC-Aの量的確保は, 菌株の選択と培養条件の工夫で達成された。また, TTC-AによるRaji細胞の多核化は, ras遺伝子の関与するシグナル伝達により制御される細胞周期の調節や細胞分化の結果生じたものと推定された。         研究成果の概要（英文）：Sufficient quantities of sesquiterpene TTC-A, which is a metabolite of Trichothecium roseum showing anti-tumor promoting and tumor promoting effects simultaneously, were obtained by selecting various strains and modifying cultural conditions. TTC-A is known to be an inducer of multinucleated Raji cells. This was deduced to result from modulation of cell cycles regulated by signal transductions associated with ras gene and cell differentiation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2009～2011;   課題番号：21580132;","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40202816.ja.htmlv"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/50433636.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"IIDA, AKIRA"},{"subitem_text_language":"en","subitem_text_value":"KANEKO, MASAFUMI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"高崎健康福祉大学薬学部; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯田,  彰"},{"creatorName":"イイダ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3663","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50433636","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"金子,  雅文"},{"creatorName":"カネコ, マサフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3664","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21580132seika.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21580132seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3215/files/KAKEN_21580132seika.pdf"},"version_id":"9e3f62ed-b46b-4267-9e6e-55484bcb2709"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"菌類","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"抗発がんプロモーター","subitem_subject_scheme":"Other"},{"subitem_subject":"発がんプロモーター","subitem_subject_scheme":"Other"},{"subitem_subject":"トリコテカン","subitem_subject_scheme":"Other"},{"subitem_subject":"Trichothecium roseum","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん予防効果を有する微生物代謝産物を利用した細胞分裂制御因子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん予防効果を有する微生物代謝産物を利用した細胞分裂制御因子の探索"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-22"},"publish_date":"2012-10-22","publish_status":"0","recid":"3215","relation_version_is_last":true,"title":["がん予防効果を有する微生物代謝産物を利用した細胞分裂制御因子の探索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:42:54.734344+00:00"}