{"created":"2023-06-20T16:34:06.638674+00:00","id":3195,"links":{},"metadata":{"_buckets":{"deposit":"4ae09805-90ab-4f57-b571-bc0abf3eb1ba"},"_deposit":{"created_by":3,"id":"3195","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3195"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003195","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3628","3627"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"(-)-epigallocatechin-3-gallate protects against neuronal cell death and improves cerebralfunction after traumatic brain injury in rats"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：緑茶は世界で広く飲用されており、その主成分は (-)-epigallocatechin gallate (EGCG)であり、抗酸化作用を有することが報告されている。今回、ラット脳外傷モデルを用いてEGCG飲料による脳外傷後の神経保護作用と脳機能の改善効果を組織学的、生化学的及び行動学的手法を用いて調べた。Wistar rats に0.1％ECGC(ECGC群)またはwater(water群)を与えて飼育し、10週齢で脳外傷を受傷させた。脳外傷後にwater飲料群においてECGC飲料群に比較しssDNA, 8-OHdG, 4-HNE陽性細胞及び過酸化脂質量の有意な増加認めた。さらに傷後EGCG飲料群でwater飲料群に比較しNeuN陽性細胞数で有意な増加を認めた。外傷後の脳機能評価においてEGCG飲料群ではwater飲料群に比較し、有意な改善効果が認められた。脳外傷後に起こる脳機能不全をEGCG飲料群は有意な改善効果をしめした。緑茶飲料は脳外傷の治療に非常に有効であることが示された。            研究成果の概要（英文）：A major component of green tea, a widely consumed beverage, is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. In this study, we investigated the effects of EGCG on cerebral function and morphology following traumatic brain injury (TBI). Six-week-old male Wistar rats that had access to normal drinking water, or water containing 0.1％ (w/v) EGCG ad libitum, received TBI with a pneumatic controlled injury device at 10 weeks of age. Immunohistochemistry and lipid peroxidation studies revealed that at 1, 3 and 7 days post-TBI, the number of 8-OHdG-, 4-HNE- and ssDNA-positive cells, and the levels of MDA around the damaged area after TBI, significantly decreased in the EGCG treatment group compared with the water group. In addition, there was a significant increase in the number of surviving neuronal cells and an improvement in cerebral dysfunction after TBI in the EGCG treatment group compared with the water group. In summary, consumption of green tea may be an effective therapy for TBI patients.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2009～2011;   課題番号：21500803;   研究分野：総合領域;   科研費の分科・細目：生活科学・食生活学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/70162443.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40330245.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SATO, TAKAO"},{"subitem_text_language":"en","subitem_text_value":"ITO, TATSUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤,  隆夫"},{"creatorName":"サトウ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤,  龍生"},{"creatorName":"イトウ, タツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21500803seika.pdf","filesize":[{"value":"487.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21500803seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3195/files/KAKEN_21500803seika.pdf"},"version_id":"391662ee-1f96-48a3-98fc-2345a9ab69d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳外傷","subitem_subject_scheme":"Other"},{"subitem_subject":"緑茶飲料","subitem_subject_scheme":"Other"},{"subitem_subject":"神経保護作用","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"EGCG","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳外傷後の緑茶飲料による神経保護作用及び神経再生促進効果の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳外傷後の緑茶飲料による神経保護作用及び神経再生促進効果の研究"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-01"},"publish_date":"2012-10-01","publish_status":"0","recid":"3195","relation_version_is_last":true,"title":["脳外傷後の緑茶飲料による神経保護作用及び神経再生促進効果の研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:43:30.642485+00:00"}