{"created":"2023-06-20T16:34:06.059208+00:00","id":3185,"links":{},"metadata":{"_buckets":{"deposit":"48c2daf3-962d-4417-8145-27d0a9226d84"},"_deposit":{"created_by":3,"id":"3185","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3185"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003185","sets":["14:2667:2685:2686","21:2669:2687:2688"]},"author_link":["3604","3605","3603","3602"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulation of APOBEC3 gene expression and its transcript splicing"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2011. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： マウスAPOBEC3遺伝子には機能的多型があり、レトロウイルス感染に自然抵抗性の系統では造血系組織、特にB リンパ球で遺伝子発現が高く、その転写産物は第5エキソンを欠くものが主体を占める。APOBEC3 遺伝子多型はそのタンパク質発現量にも影響するが、これは第5エキソンの有無が翻訳効率を決定するためである。第5 エキソン取り込みの有無を決めるのは、第4イントロンのRNA 分岐部位多型と第5エキソン内の単一塩基多型であることを解明した。          研究成果の概要（英文）： Polymorphisms at the mouse APOBEC3 (mA3) gene locus have　been associated with different susceptibilities to infection with mouse leukemia viruses.　In virus-resistant C57BL/6 (B6) mice, mA3 transcripts and protein are more abundant　than those in susceptible BALB/c mice, and these strains of mice also express mA3 transcripts with different splicing patterns. B6 mice express predominantly the exon　5-deficient transcript, which confer more efficient translation than the full-length　transcript. By employing in vitro splicing assays using genomic DNA clones, we identified　two critical determinants that regulate exon 5 inclusion into mA3 transcripts: the number　of TCCT repeats upstream of exon 5 and the newly identified single nucleotide　polymorphism within exon 5 located 12 bases upstream of the exon 5/intron 5 boundary.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（B）;  研究期間：2009～2011;   課題番号：21390143;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学･ウイルス学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60167757.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/60297629.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30344500.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90528564.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MIYAZAWA, MASAAKI"},{"subitem_text_language":"en","subitem_text_value":"KAWAHARA, SACHIYO"},{"subitem_text_language":"en","subitem_text_value":"HAKATA, YOSHIYUKI"},{"subitem_text_language":"en","subitem_text_value":"TAKAMURA, SHIKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮澤,  正顯"},{"creatorName":"ミヤザワ, マサアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"河原,  佐智代"},{"creatorName":"カワハラ, サチヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"博多,  義之"},{"creatorName":"ハカタ., ヨシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高村,  史記"},{"creatorName":"タカムラ, シキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21390143seika.pdf","filesize":[{"value":"379.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21390143seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3185/files/KAKEN_21390143seika.pdf"},"version_id":"b598bf31-da63-44b4-a5b5-96914f5a5741"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"個体","subitem_subject_scheme":"Other"},{"subitem_subject":"感染抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"宿主因子","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"同種由来レトロウイルス感染を制御するAPOBEC3の発現調節機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"同種由来レトロウイルス感染を制御するAPOBEC3の発現調節機構"}]},"item_type_id":"8","owner":"3","path":["2686","2688"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-25"},"publish_date":"2012-09-25","publish_status":"0","recid":"3185","relation_version_is_last":true,"title":["同種由来レトロウイルス感染を制御するAPOBEC3の発現調節機構"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:43:47.657078+00:00"}