{"created":"2023-06-20T16:34:05.582504+00:00","id":3175,"links":{},"metadata":{"_buckets":{"deposit":"4dd0bf25-a609-47c2-bc1c-c1b441cb808d"},"_deposit":{"created_by":3,"id":"3175","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3175"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003175","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3571","3570","3573","3572"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Basic research for development of CTL-inducible vaccine against West Nile virus using recombinant E protein"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ウエストナイルウイルス(WNV)は、時に致死性の脳炎・髄膜炎を発症させるヒト感染性ウイルスであるが、未だヒト用の実用ワクチンは存在しない。近縁のウイルスで得られた知見より、エンベロープ(Ｅ)蛋白が防御免疫を誘導するものと期待されている。本研究においては、組換えWNV E 蛋白とcross-presentation 誘導性アジュバントとの組み合わせによる、中和抗体のみならずCTL も誘導する組換え成分ワクチンの開発を目的として、数種類のWNV E 蛋白質発現系を確立し、またCTL の標的細胞を樹立した。     研究成果の概要（英文）：West Nile virus (WNV) is the human-infectious virus, whichsometimes causes lethal encephalitis / meningitis, and the vaccine for human use has not been developed yet. Based on the findings concerning its relative viruses, it is anticipated that the envelope (E) protein should induce protective immunity. In the present study, we have established several recombinant WNV E protein expression systems and the CTL target cells in order to develop the recombinant component vaccine against WNV infection, which induces not only neutralizing antibody but also CTL, using recombinant WNV E protein combined with cross-presentation inducing adjuvant.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2007～2010;   課題番号：19590604;   研究分野：免疫学;   科研費の分科・細目：社会医学・衛生学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90247982"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40135786"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MASAKI, HIDEYUKI"},{"subitem_text_language":"en","subitem_text_value":"KONISHI, EIJI"},{"subitem_text_language":"en","subitem_text_value":"SATO, MAYUMI"},{"subitem_text_language":"en","subitem_text_value":"KUWAHARA, MIWA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"神戸大学大学院保健学研究科; 准教授"},{"subitem_text_value":"神戸大学・大学院保健学研究科; 大学院生"},{"subitem_text_value":"神戸大学・大学院保健学研究科; 大学院生"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"正木,  秀幸"},{"creatorName":"マサキ, ヒデユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小西,  英二"},{"creatorName":"コニシ, エイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤,  真弓"},{"creatorName":"サトウ, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"桑原,  三和"},{"creatorName":"クワハラ, ミワ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19590604seika.pdf","filesize":[{"value":"128.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19590604seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3175/files/KAKEN_19590604seika.pdf"},"version_id":"6eebbcbf-1071-4016-86ff-829ac23d3dba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウエストナイルウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"Ｅ蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"成分ワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"組換えワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"ＣＴＬ","subitem_subject_scheme":"Other"},{"subitem_subject":"cross-presentation","subitem_subject_scheme":"Other"},{"subitem_subject":"中和抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"感染防御","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"組換えウエストナイルウイルスＥ蛋白質によるＣＴＬ誘導性ワクチンの基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"組換えウエストナイルウイルスＥ蛋白質によるＣＴＬ誘導性ワクチンの基礎的研究"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3175","relation_version_is_last":true,"title":["組換えウエストナイルウイルスＥ蛋白質によるＣＴＬ誘導性ワクチンの基礎的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:05.515159+00:00"}