{"created":"2023-06-20T16:34:04.951655+00:00","id":3165,"links":{},"metadata":{"_buckets":{"deposit":"3f1f024c-0fe0-45f1-bd74-06064eb56897"},"_deposit":{"created_by":3,"id":"3165","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3165"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003165","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3547","3548","3546"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of the gasotransmitter hydrogen sulfide in neurogenic pain"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：硫化水素の疼痛情報伝達促進メカニズムにCav3.2 T型カルシウムチャネルが関与することを明らかにした。また、L5脊髄神経切断神経障害性疼痛モデルを作成し、痛覚過敏・アロディニアの保持に内因性硫化水素によるCav3.2の活性化が関与すること、さらに、本モデルではCav3.2の発現誘導がおこっていることを見出し、硫化水素／Cav3.2系が神経因性疼痛の新たな治療標的になりうることを明らかにした。      研究成果の概要（英文）：We first demonstrated the involvement of Cav3.2 T-type calcium channels in hydrogen sulfide-induced facilitation of nociception. We then found that, in rats with L5 spinal nerve injury, the activation of Cav3.2 by endogenous hydrogen sulfide was involved in the maintenance of hyperalgesia/allodynia, and Cav3.2 was upregulated, suggesting that the hydrogen sulfide/Cav3.2 pathway should be a therapeutic target for treatment of neurogenic pain.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2008～2010;   課題番号：20602016;   研究分野：時限;   科研費の分科・細目：疼痛学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20177728"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60145224"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90271410"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWABATA, ATSUFUMI"},{"subitem_text_language":"en","subitem_text_value":"YOSHIDA, SHIGERU"},{"subitem_text_language":"en","subitem_text_value":"SEKIGUCHI, FUMIKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学理工学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川畑,  篤史"},{"creatorName":"カワバタ, アツフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉田,  繁"},{"creatorName":"ヨシダ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"関口,  富美子"},{"creatorName":"セキグチ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20602016seika.pdf","filesize":[{"value":"779.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20602016seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3165/files/KAKEN_20602016seika.pdf"},"version_id":"9d7025d6-c599-49a6-b879-795e4c278569"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ニューロパチー","subitem_subject_scheme":"Other"},{"subitem_subject":"神経障害性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"生体内ガス","subitem_subject_scheme":"Other"},{"subitem_subject":"硫化水素","subitem_subject_scheme":"Other"},{"subitem_subject":"T型カルシウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"痛み","subitem_subject_scheme":"Other"},{"subitem_subject":"神経因性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"siRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"気体メディエーター硫化水素の神経因性疼痛への関与について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"気体メディエーター硫化水素の神経因性疼痛への関与について"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3165","relation_version_is_last":true,"title":["気体メディエーター硫化水素の神経因性疼痛への関与について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:31.200145+00:00"}