{"created":"2023-06-20T16:34:04.822889+00:00","id":3163,"links":{},"metadata":{"_buckets":{"deposit":"e511c3a0-52b4-4bdf-9a69-d2121d7609de"},"_deposit":{"created_by":3,"id":"3163","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3163"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003163","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3537","3542","3540","3539","3538","3541"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Latently Infected HSV in the Cornea"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：我々は、全層角膜移植時に得られた28レシピエント角膜28眼中、HSV-1 DNAは10 眼 (35.7％), HSV-2 DNA は1 眼 (3.6％), VZV DNAは9眼(32.1％), CMV DNAは 2 眼 (7.1％), AdV DNAは 0 眼 (0％)で検出された。 そして、HSV DNAの涙液中での検出率を調べた。正常眼は12眼中1眼、8.3 ％、ドライアイは11眼中3眼、27.3 ％、結膜炎は15眼中4眼、26.7 ％であった。 また、HSV-1潜伏感染再活性化マウスモデルにおいて、薬物が再活性化抑制に効果を認めるか調べ、ブロムフェナックNa点眼、AMP筋肉注射、ゲルダナマイシン腹腔下注射は、有意なHSV-1再活性化抑制効果を認めた。      研究成果の概要（英文）： We detected herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV), and cytomegalovirus (CMV) DNAs in recipient corneal buttons taken at the time of penetrating keratoplasty. HSV-1, HSV-2, VZV, and CMV DNAs were detected in 10, 1, 9, and 2 of the 27 recipient corneal buttons, respectively. The rates of HSV DNA positivity were 1/12 (8.3 ％), 3/11 (27.3 ％), and 4/15 (26.7 ％) in normal eye, dry eye, and conjunctivitis, respectively. Seven medications were investigated for their efficacy in suppressing HSV-1 reactivation in mouse model. Bromfenac Na eye drop, intramuscular AMP, and intraperitoneal geldanamycin suppressed the HSV-1 reactivation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2008～2010;   課題番号：20592084;   研究分野：眼科、感染症;   科研費の分科・細目：外科系臨床医学 眼科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20162737"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40218938"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/00222646"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90238262"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30309314"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/50399119"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SHIMOMURA, YOSHIKAZU"},{"subitem_text_language":"en","subitem_text_value":"FUKUDA, MASAHIKO"},{"subitem_text_language":"en","subitem_text_value":"ABE, KOSUKE"},{"subitem_text_language":"en","subitem_text_value":"HIGAKI, SHIRO"},{"subitem_text_language":"en","subitem_text_value":"SUGAHARA, DAISUKE"},{"subitem_text_language":"en","subitem_text_value":"SUGIOKA, KOJI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部附属病院; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下村,  嘉一"},{"creatorName":"シモムラ, ヨシカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"福田,  昌彦"},{"creatorName":"フクダ, マサヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"阿部,  考助"},{"creatorName":"アベ, コウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"檜垣,  史郎"},{"creatorName":"ヒガキ, シロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菅原,  大輔"},{"creatorName":"スガハラ, ダイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉岡,  孝二"},{"creatorName":"スギオカ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20592084seika.pdf","filesize":[{"value":"297.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20592084seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3163/files/KAKEN_20592084seika.pdf"},"version_id":"5a626d59-f146-4cbe-88eb-db76b76c20c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"感染症","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"組織","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜ヘルペス","subitem_subject_scheme":"Other"},{"subitem_subject":"PCR","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"角膜内潜伏感染ヘルペスウイルスの動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"角膜内潜伏感染ヘルペスウイルスの動態"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3163","relation_version_is_last":true,"title":["角膜内潜伏感染ヘルペスウイルスの動態"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:35.011625+00:00"}