{"created":"2023-06-20T16:34:04.692675+00:00","id":3161,"links":{},"metadata":{"_buckets":{"deposit":"bb365293-64ff-4fba-9c04-d44c09845375"},"_deposit":{"created_by":3,"id":"3161","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3161"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003161","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3532","3533"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Gene Expression Profiling of Human Endolymphatic Sac by DNA Microarray Analysis"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：難治性メニエール病確実例および対照群の内リンパ嚢に発現する多数の遺伝子群の遺伝子動態を網羅的に解析した。メニエール病確実例（MD 群）内リンパ嚢での遺伝子発現量が0.33倍以下に低下したのは1214 遺伝子（16 ％）、遺伝子発現量が0.33倍以下に低下したのは502遺伝子（6.8％）あった。これらの遺伝子群における発現量の変化が、内リンパ水腫の形成に関係するものなのか、あるいは、存在する内リンパ水腫の結果であるのか、さらに解析を進めていく予定である。        研究成果の概要（英文）：To identify genesrelated to the pathogenesis of Meniere’s disease (MD), gene expression profilings of the human endolymphatic sac (ES) harvested from the cases of both MD and Vestibular Schwannoma (VS) were determined by DNA microarray analysis. In the present study, we could successfully perform the DNA microarray analysis of the human ES. In spite of a tiny amount of total RNA obtained from this specialized tissue, approximately 7500 genes were identified to be there. In comparison of gene expression profiling between the human ES of both MD and VS cases, some genes were significantly up-regulated and others were down-regulated in the human ES of MD cases. The DNA microarray analysis in the present study may provide a large-scale understanding of gene expression profiling in the human ES and make it possible in future to identified the genes crossly related to the pathogenesis of MD.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2008～2010;   課題番号：20591982;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・耳鼻・咽喉科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40243224"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30343255"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"DOI, KATSUMI"},{"subitem_text_language":"en","subitem_text_value":"KITAHARA, TADASHI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"大阪大学医学系研究科; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井,  勝美"},{"creatorName":"ドイ, カツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3532","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30343255","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"北原,  糺"},{"creatorName":"キタハラ, タダシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3533","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20591982seika.pdf","filesize":[{"value":"49.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20591982seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3161/files/KAKEN_20591982seika.pdf"},"version_id":"ad158a0a-335f-4a93-b497-937ecdc66d4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メニエール病","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト内リンパ嚢","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAマイクロアレイ","subitem_subject_scheme":"Other"},{"subitem_subject":"聴神経腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DNAマイクロアレイによる内耳病態の解明--ヒト内リンパ嚢遺伝子の動態解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNAマイクロアレイによる内耳病態の解明--ヒト内リンパ嚢遺伝子の動態解析"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3161","relation_version_is_last":true,"title":["DNAマイクロアレイによる内耳病態の解明--ヒト内リンパ嚢遺伝子の動態解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:40.252324+00:00"}