{"created":"2023-06-20T16:34:04.563679+00:00","id":3159,"links":{},"metadata":{"_buckets":{"deposit":"136eda58-a822-4d16-b56a-4ae02fa21713"},"_deposit":{"created_by":3,"id":"3159","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3159"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003159","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3525","3524"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Physiology and application of deimination of humnan hair follicle S100A3"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： ヒトS100A3は毛嚢において生合成された後、同組織に局在する脱イミノ化酵素によりEFハンド領域の構造が変化し、本来のCa2+結合蛋白質として機能すること、またその際４量体への移行が伴うことが明かとなった。ついで、Ca^<2+>/Zn^<2+>結合型S100A3の結晶解析を行い、今まで報告されていなかったジスルフィド（SS）結合が二か所にあることが分かった。そのSS結合はPAD3によるシトルリン化とCa^<2+>結合に重要な役割を果たしていることが示された。    研究成果の概要（英文）：S100A3 protein specifically expressed in the cuticular cells of hair follicle. Human S100A3 is characterized by two disulphide bridges, a preformed Zn^<2+>-binding site, and a specific citrullination site by deimination. Conversion to the citrulline residues, symmetrically located on the S100A3 dimer plane - causes the assembly of the Ca^<2+>-bound S100A3 homotetramer. S100A3 acts as a Ca^<2+> buffering protein providing Ca^<2+> ions in turn to the deimination.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2008～2010;   課題番号：20591358;   研究分野：皮膚科学;   科研費の分科・細目：皮膚科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90160986"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30122063"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWADA, AKIRA"},{"subitem_text_language":"en","subitem_text_value":"TAKAHARA, HIDENARI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"茨城大学農学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川田,  暁"},{"creatorName":"カワダ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3524","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30122063","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"高原,  英成"},{"creatorName":"タカハラ, ヒデナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3525","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20591358seika.pdf","filesize":[{"value":"486.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20591358seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3159/files/KAKEN_20591358seika.pdf"},"version_id":"2177e81c-1572-49c2-87b7-d813c2b3ea32"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ｓ１００Ａ３","subitem_subject_scheme":"Other"},{"subitem_subject":"脱イミノ化反応","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト毛嚢","subitem_subject_scheme":"Other"},{"subitem_subject":"peptidylarginine deimase","subitem_subject_scheme":"Other"},{"subitem_subject":"Ｘ線構造解析","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム結合タンパク質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト毛嚢におけるＳ１００Ａ３の脱イミノ化反応の生理的機能とその応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト毛嚢におけるＳ１００Ａ３の脱イミノ化反応の生理的機能とその応用"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3159","relation_version_is_last":true,"title":["ヒト毛嚢におけるＳ１００Ａ３の脱イミノ化反応の生理的機能とその応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:44.864211+00:00"}