{"created":"2023-06-20T16:34:04.242480+00:00","id":3154,"links":{},"metadata":{"_buckets":{"deposit":"f18438c1-3837-4666-9bcc-69594878bdb6"},"_deposit":{"created_by":3,"id":"3154","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3154"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003154","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3510","3511","3509","3508"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies of food ingredients which improve the physiological function of adipocyte through modulation of adipocytokine secretion"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：生活習慣病発症に関わる肥満は脂肪細胞に大量の油滴が蓄積した状態であり、肥満は動脈硬化症進展の促進因子でもある。また、動脈硬化の進展には血管平滑筋細胞の内膜への遊走が関わっている。アントシアニンのcyanidin-3-glucoside（C3G）やある種の食品成分は脂肪細胞への油滴蓄積を抑制して脂肪細胞の肥大化を抑制するだけではなく、脂肪細胞存在下における血管平滑筋細胞の遊走を抑制して動脈硬化症の進展も抑制することを明らかにした。       研究成果の概要（英文）：Obesity is one of the reasons that cause the lifestyle disease which includes atherosclerosis. In obesity, adipocyte accumulates a large amount of oil in its cytoplasm. And the obesity is the exacerbation factor for atherosclerosis. Also, the migration of smooth muscle cells (SMC) into intima is involved in progression of atherosclerosis. A definite food ingredient such as cyanidine-3-glucoside (C3G) inhibited the accumulation of oil in adipocyte and suppressed the enlargement of adipocyte. Furthermore, the defined food ingredients inhibited the migration of SMC in the presence of adipocyte, suggesting that they might be inhibit the progression of atherosclerosis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2008～2010;   課題番号：20590241;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・環境生理学（含体力医学・栄養生理学）","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30193791"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40030879"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20185432"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"UESHIMA, SHIGERU"},{"subitem_text_language":"en","subitem_text_value":"MATSUO, OSAMU"},{"subitem_text_language":"en","subitem_text_value":"OKADA, KIYOTAKA"},{"subitem_text_language":"en","subitem_text_value":"YAMASHITA, RINA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学農学部; 助手"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上嶋,  繁"},{"creatorName":"ウエシマ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3508","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90510876","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"松尾,  理"},{"creatorName":"マツオ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田,  清孝"},{"creatorName":"オカダ, キヨタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下,  里奈"},{"creatorName":"ヤマシタ, リナ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3511","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20590241seika.pdf","filesize":[{"value":"409.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20590241seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3154/files/KAKEN_20590241seika.pdf"},"version_id":"c9a2864d-e6e6-4dd7-a8ac-e827cf63c112"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"血管平滑筋細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"アディポサイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"アディポネクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"PAI-1","subitem_subject_scheme":"Other"},{"subitem_subject":"C3G","subitem_subject_scheme":"Other"},{"subitem_subject":"遊走能","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アディポサイトカイン分泌を介した脂肪細胞の生理機能を改善する食物成分の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アディポサイトカイン分泌を介した脂肪細胞の生理機能を改善する食物成分の解析"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3154","relation_version_is_last":true,"title":["アディポサイトカイン分泌を介した脂肪細胞の生理機能を改善する食物成分の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:55.449147+00:00"}