{"created":"2023-06-20T16:34:04.115807+00:00","id":3152,"links":{},"metadata":{"_buckets":{"deposit":"aabe380e-4674-4431-8d62-0ce064833aa2"},"_deposit":{"created_by":3,"id":"3152","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3152"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003152","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3498","3500","3501","3502","3499"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"New synthetic peptide enhances plasminogen activation and thrombolysis"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：スタフィロキナーゼのアミノ酸配列中の一部の配列に相当する合成ペプチド(SP)は、プラスミノーゲン (Plg)に結合してPlg activator (PA)による活性化を促進させた。この結合はPlg B鎖のC末端側の一部を構成する合成ペプチドで阻害された。SPのGlu-Plgへの結合は、Glu-Plgの構造変化を誘導した。SPはマウス血栓モデルに対して、血流の再開通を促進させた。よって、SPはPlg活性化を促進することにより血栓溶解促進作用を示す。        研究成果の概要（英文）：A new synthetic nonadecapeptide (SP) corresponding to Glu22-Leu40 of staphylokinase molecule bound to plasminogen (Plg) and enhanced the activation of Plg by Plg activator (PA). This binding was completely inhibited by synthetic peptide corresponding to C-terminal region of plasmin B-chain. SP binds to Glu-Plg, and induces structural changes of Glu-Plg. When SP was administrated in mouse thrombosis model, earlier recanalization was observed than in mice with vehicle administration. Thus, SP enhanced Plg activation and induced effective thrombolysis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2008～2010;   課題番号：20590222;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・生理学一般","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20185432"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40030879"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/70388510"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30193791"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90260281"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"H研究分担者:連携研究者（平成22年）"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"OKADA, KIYOTAKA"},{"subitem_text_language":"en","subitem_text_value":"MATSUO, OSAMU"},{"subitem_text_language":"en","subitem_text_value":"KAWAO, NAOYUKI"},{"subitem_text_language":"en","subitem_text_value":"UESHIMA, SHIGERU"},{"subitem_text_language":"en","subitem_text_value":"NAGAI, NOBUO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"長浜バイオ大学バイオサイエンス学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田,  清孝"},{"creatorName":"オカダ, キヨタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"松尾,  理"},{"creatorName":"マツオ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河尾,  直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上嶋,  繁"},{"creatorName":"ウエシマ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永井,  信夫"},{"creatorName":"ナガイ, ノブオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20590222seika.pdf","filesize":[{"value":"713.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20590222seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3152/files/KAKEN_20590222seika.pdf"},"version_id":"77575a0b-e8cb-4521-ab5c-b148f8b4437d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血液凝固","subitem_subject_scheme":"Other"},{"subitem_subject":"血液レオロジー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規ペプチドによるプラスミノーゲン活性化促進機構の解析とその応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規ペプチドによるプラスミノーゲン活性化促進機構の解析とその応用"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3152","relation_version_is_last":true,"title":["新規ペプチドによるプラスミノーゲン活性化促進機構の解析とその応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:44:59.701069+00:00"}