{"created":"2023-06-20T16:34:04.050493+00:00","id":3151,"links":{},"metadata":{"_buckets":{"deposit":"3e88de7e-080f-4f1b-831f-0e26b7fe402b"},"_deposit":{"created_by":3,"id":"3151","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3151"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003151","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3497","3495","3496"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Morphological approach to the photo signal transduction pathway of the circadian clock"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：視交叉上核(SCN)におけるシグナル伝達経路を明らかにするために、SCN におけるペプチド産生細胞とその受容体を持つ細胞の局在を調べた。視交叉上核の腹外側部(VLSCN)にはVIP 細胞が、背内側部(DMSCN)にはVIP の受容体であるVPAC2 細胞の局在を認めた。また、DMSCN とVLSCN に分離したスライス培養に、VIP を投与するとDMSCN のみ位相に大きなシフトを認めた。以上の結果からVLSCN からDMSCN にVIP がVPAC2 受容体を介して位相情報の伝達を行っていることが示唆された。       研究成果の概要（英文）：We investigated the photo signal transduction pathway in the suprachiasmatic nucleus (SCN), the mammalian circadian centers. By using in situ hybridization technique, we examined the localization of vasoactive intestinal peptide (VIP) mRNA and VPAC2 mRNA (one of the VIP receptors)- expressing neurons in the rat SCN. We found that VIP mRNA was strongly expressed in the ventrolateral SCN (VLSCN). In contrast, VPAC2 mRNA was strongly expressed in the dorsomedial SCN (DMSCN). Moreover, to investigate regional response to VIP, VIP administration to the SCN slice culture after isolation of DM from VL by a knife showed the large phase shift in only separating-DM. It is highly probable that VLSCN regulate the phase of DMSCN by VIP- VPAC2R. The findings suggest that VIP acting via the VPAC2 receptor is implicated as a key signaling pathway from VLSCN to DMSCN.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2008～2010;   課題番号：20590202;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・解剖学一般（含組織学・発生学）","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/80155960"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20275192"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30077664"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAGANO, MAMORU"},{"subitem_text_language":"en","subitem_text_value":"SHIGEYOSHI, YASUFUMI"},{"subitem_text_language":"en","subitem_text_value":"FUJIOKA, ATSUKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長野,  護"},{"creatorName":"ナガノ, マモル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"重吉,  康史"},{"creatorName":"シゲヨシ, ヤスフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤岡,  厚子"},{"creatorName":"フジオカ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20590202seika.pdf","filesize":[{"value":"206.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20590202seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3151/files/KAKEN_20590202seika.pdf"},"version_id":"44809e29-cd51-42ba-a2e8-01c30941a021"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"},{"subitem_subject":"概日時計","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"体内時計の中枢である視交叉上核における光シグナル伝達経路の形態学的解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"体内時計の中枢である視交叉上核における光シグナル伝達経路の形態学的解明"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3151","relation_version_is_last":true,"title":["体内時計の中枢である視交叉上核における光シグナル伝達経路の形態学的解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:01.519264+00:00"}