{"created":"2023-06-20T16:34:03.986321+00:00","id":3150,"links":{},"metadata":{"_buckets":{"deposit":"f706cc70-1e51-4a1f-aed6-c59ea56ee585"},"_deposit":{"created_by":3,"id":"3150","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3150"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003150","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3494","3493"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies on biosynthesis and metabolism of the glutathione conjugated bile acids"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：胆汁酸の代謝活性中間体を経るグルタチオン（GSH）抱合体の生成と代謝機構の解明を目的として、胆汁酸がin vitro、in vivoでGSH並びにN-アセチルシステイン（NAC）との抱合を受けることを明らかにするとともに、ラット及びヒト胆汁中にGSH抱合型胆汁酸が排出されていることを実証し、胆汁酸の新規代謝経路として提示した。また、NAC抱合型ウルソデオキシコール酸が肝機能改善薬のプロドラッグとなる可能性を示す基礎的知見を得た。        研究成果の概要（英文）：In order to elucidate the mechanism on the formation and metabolism of glutathione (GSH) conjugated bile acids via their reactive intermediates, we demonstrated that bile acid were tansacylated with GSH and N-acetylcysteine (NAC) by in vitro and in vivo studies. In addition, we clarified that the several kinds of glutathione conjugated bile acids were excreted into the bile of rats and patients with biliary diseases. We also showed the NAC conjugated ursodeoxycholic acid could be a prodrug for hepatobiliary fuction improvement drug.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2008～2010;   課題番号：20590164;   研究分野：臨床分析化学;   科研費の分科・細目：薬学・医療系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/70242526"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90111301"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MITAMURA, KUNIKO"},{"subitem_text_language":"en","subitem_text_value":"IKEGAWA, SHIGEO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三田村,  邦子"},{"creatorName":"ミタムラ, クニコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池川,  繁男"},{"creatorName":"イケガワ, シゲオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20590164seika.pdf","filesize":[{"value":"293.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20590164seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3150/files/KAKEN_20590164seika.pdf"},"version_id":"d53bfdd9-16b7-4c18-be61-c2f64ae77420"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胆汁酸","subitem_subject_scheme":"Other"},{"subitem_subject":"グルタチオン","subitem_subject_scheme":"Other"},{"subitem_subject":"N-アセチルシステイン","subitem_subject_scheme":"Other"},{"subitem_subject":"エレクトロスプレーイオン化","subitem_subject_scheme":"Other"},{"subitem_subject":"質量分析法","subitem_subject_scheme":"Other"},{"subitem_subject":"胆汁","subitem_subject_scheme":"Other"},{"subitem_subject":"プロドラッグ","subitem_subject_scheme":"Other"},{"subitem_subject":"硫酸抱合","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"グルタチオン抱合型胆汁酸の生成と代謝機構に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グルタチオン抱合型胆汁酸の生成と代謝機構に関する研究"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3150","relation_version_is_last":true,"title":["グルタチオン抱合型胆汁酸の生成と代謝機構に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:04.284327+00:00"}