{"created":"2023-06-20T16:34:03.860020+00:00","id":3148,"links":{},"metadata":{"_buckets":{"deposit":"700fc0a0-8223-441d-aa67-46b94709b14c"},"_deposit":{"created_by":3,"id":"3148","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3148"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003148","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3490","3491"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study on effects of Helicobacter pylori infection on expression and function of proteinase—activated receptors in gastric mucosal epithelium."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): 胃癌患者の癌化した胃粘膜組織では、ヘリコバクター・ピロリ(H. pylori)感染が高い部位でproteinase-activated receptor-1(PAR1)発現量が増加している傾向が見られ、H.pylori感染による胃癌の発生や進行にとPAR1発現増加が関与する可能性が考えられた。一方、H.pyloriのもつプロテーゼについて種々の細胞を用いて反応性を検討した結果、PAR1、PAR2、PAR4を活性化するプロテアーゼの存在は認められなかった。      研究成果の概要(英文) : In the cancer area of gastric mucosal epithelium from gastric cancer patients, we found a tendency that expression of proteinase-activated ceptor-1(PAR1) was positively correlated with infection levels of Helicobacter pylori (H. pylori), suggesting involvement of increased expression of PAR1 in the development of H. pylori-related gastric cancer. We also determined if H. pylori might possess PAR-activating proteinases in various cell lines. However, we did not find any proteinases that activate PAR1, PAR2 or PAR4, in the H. pylori extracts.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2008～2010;   課題番号：20590097;   研究分野：医歯薬学;   科研費の分科・細目：生物系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90271410"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20177728"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SEKIGUCHI, FUMIKO"},{"subitem_text_language":"en","subitem_text_value":"KAWABATA, ATSUFUMI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関口,  富美子"},{"creatorName":"セキグチ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川畑,  篤史"},{"creatorName":"カワバタ, アツフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20590097seika.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20590097seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3148/files/KAKEN_20590097seika.pdf"},"version_id":"b603532b-87f1-4596-ae98-74663c235c55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"薬理学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃粘膜上皮のプロテアーゼ活性化受容体発現と機能に対するピロリ菌感染の影響について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃粘膜上皮のプロテアーゼ活性化受容体発現と機能に対するピロリ菌感染の影響について"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3148","relation_version_is_last":true,"title":["胃粘膜上皮のプロテアーゼ活性化受容体発現と機能に対するピロリ菌感染の影響について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:06.278345+00:00"}