{"created":"2023-06-20T16:34:03.766443+00:00","id":3146,"links":{},"metadata":{"_buckets":{"deposit":"04d1b7a6-481a-4203-9d1a-b0380f541de7"},"_deposit":{"created_by":3,"id":"3146","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3146"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003146","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3486","3484","3487","3485"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanisms of ABC transporter, Bcrp1, on the regulation of differentiation in mouse embryonic stem cells"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 幹細胞の分離・同定の指標の一つであるside population細胞（SP細胞）をつくり出すABCトランスポーターファミリー・Bcrp1がES細胞の分化制御に果たす役割について検討した。その結果、(1)Bcrp1 mRNAアイソフォームの選択的発現とその発現制御、(2)Bcrp1の過剰発現によるOct3/4の発現亢進と内胚葉への分化誘導、(3)癌抑制遺伝子産物との相互作用などについて新たな知見が得られた。       研究成果の概要（英文）：This study examined the function of ABC transporter, Bcrp1, on the differentiation of mouse ES cells. Bcrp1 defines the side population cell phenotype, which indicates the presumptive functional regulator of stem cells. The results may be summarized as follows: (1) the alternative transcription of Bcrp1 mRNA isoforms and analysis of the cis-element, (2) the upregulation of Oct3/4 gene by Bcrp1 overexpression and its induction of ES cells into endodermal cells, and (3) the possibility of Bcrp1 associating with the products of tumor suppressor gene with Bcrp1 protein.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）;  研究期間：2008～2010;   課題番号：20580316;   研究分野：農学;   科研費の分科・細目：畜産学・獣医学、応用動物科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/10322265"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/10298937"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20298938"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/70309269"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MITANI, TASUKU"},{"subitem_text_language":"en","subitem_text_value":"SAEKI, KAZUHIRO"},{"subitem_text_language":"en","subitem_text_value":"MATSUMOTO, KAZUYA"},{"subitem_text_language":"en","subitem_text_value":"TAGUCHI, YOSHITOMO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学先端技術総合研究所; 准教授"},{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"近畿大学生物理工学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三谷,  匡"},{"creatorName":"ミタニ, タスク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐伯,  和弘"},{"creatorName":"サエキ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本,  和也"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口,  善智"},{"creatorName":"タグチ, ヨシトモ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20580316seika.pdf","filesize":[{"value":"243.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20580316seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3146/files/KAKEN_20580316seika.pdf"},"version_id":"f0d43186-ab3d-4018-837d-a18101a92c72"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"発生工学","subitem_subject_scheme":"Other"},{"subitem_subject":"ES細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCトランスポーター","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウス胚性幹細胞の分化制御におけるＡＢＣトランスポーター、Ｂｃｒｐ１の役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス胚性幹細胞の分化制御におけるＡＢＣトランスポーター、Ｂｃｒｐ１の役割の解明"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3146","relation_version_is_last":true,"title":["マウス胚性幹細胞の分化制御におけるＡＢＣトランスポーター、Ｂｃｒｐ１の役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:11.133307+00:00"}