{"created":"2023-06-20T16:34:03.090178+00:00","id":3134,"links":{},"metadata":{"_buckets":{"deposit":"e49c6260-7c0a-4c2f-82ef-8a49716123bc"},"_deposit":{"created_by":3,"id":"3134","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3134"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003134","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3468","3467","3469","3470"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular Genetic Analysis of the MAPK Signaling Pathway"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は、分裂酵母モデル生物を用いた独自のゲノム薬理学的手法により、細胞の増殖・がん化に重要な役割をもつMAPK の制御因子の同定と制御機構の解明を目的とする。本研究の成果として、1) Pmk1 MAPK 抑制因子として、タイプ2C ホスファターゼであるPtc1,Ptc3, 細胞表面膜タンパク質であるEcm33 を同定した。2) Pmk1 MAPK 標的因子として、転写因子Atf1, RNA 結合タンパク質Nrd1 を同定した。3)上記のMAPK の制御因子群によるMAPK のフィードバック制御機構を発見した。4) 新規MAPK シグナル阻害活性をもつ化合物も同定した。       研究成果の概要（英文）：This project aims to identify regulators of MAPK signaling using fission yeast S. pombe as a model organism. We identified negative regulators of Pmk1 MAPK, such as ptc1+, ptc3+, encoding PP2Cs, and ecm33+, encoding a cell surface protein. We also identified targets of Pmk1 including the Atf1 transcription factor and the Nrd1RNA-binding protein. We also demonstrated feedback mechanisms involving these regulators of Pmk1 MAPK and identified several compounds with potent MAPK inhibitory action.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（B）;  研究期間：2007～2010;   課題番号：19390024;   研究分野：細胞内情報伝達、ゲノム薬理;   科研費の分科・細目：生物系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90294206"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/00388498"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30101405"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20142599"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SUGIURA, REIKO"},{"subitem_text_language":"en","subitem_text_value":"KITA, AYAKO"},{"subitem_text_language":"en","subitem_text_value":"KAKEHI, KAZUAKI"},{"subitem_text_language":"en","subitem_text_value":"MURAOKA, OSAMU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 助教"},{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉浦,  麗子"},{"creatorName":"スギウラ, レイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"喜多,  綾子"},{"creatorName":"キタ, アヤコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"掛樋,  一晃"},{"creatorName":"カケヒ, カズアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村岡,  修"},{"creatorName":"ムラオカ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19390024seika.pdf","filesize":[{"value":"616.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19390024seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3134/files/KAKEN_19390024seika.pdf"},"version_id":"f8481e92-b2f2-4347-ae2b-eb02fa26cc5b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MAP キナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム創薬","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム薬理","subitem_subject_scheme":"Other"},{"subitem_subject":"分裂酵母モデル生物","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA 結合タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"分子遺伝学","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパク質リン酸化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ゲノム創薬をめざしたMAPキナーゼシグナルの制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ゲノム創薬をめざしたMAPキナーゼシグナルの制御機構の解明"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3134","relation_version_is_last":true,"title":["ゲノム創薬をめざしたMAPキナーゼシグナルの制御機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:33.633930+00:00"}