{"created":"2023-06-20T16:34:02.578426+00:00","id":3122,"links":{},"metadata":{"_buckets":{"deposit":"bba71bdb-6a2a-477a-bffb-c54b2efa7c31"},"_deposit":{"created_by":3,"id":"3122","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3122"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003122","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3440","3437","3438","3436","3439"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Long-term voluntary exercise improves the efficacy of cerebral angiogenesis and neurogenesis in stroke-prone genetically hypertensive rats"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：運動療法の予防・治療効果の一因として造血幹細胞や血管内皮前駆細胞(EPC)、神経幹細胞の増加を予想し、ヒト本態性高血圧症病態モデルSHRSPを用いて検討した。運動群では発症前および発症後速やかに骨髄・末梢血中のEPCや造血幹細胞が増加し、脳病変部周囲の微小血管や神経幹細胞数も増加した。またEPCの誘導、移動に必須のCXCL12やVEGF、神経新生に関与するBDNFとそのシグナル分子ERKやCREBの活性化が認められた。     研究成果の概要（英文）：Beneficial effects of long-term exercise (EX) may relate to increase endothelial and hematopoietic progenitors, and neuronal stem cells. In EX SHRSP, the number and activity of EPC and hematopoietic cells in bone marrow and peripheral blood cells were increased before and after stroke. The numbers of microvessels and neuronal stem cells around cerebral lesion were increased in EX, coincident with the appearance of EPC. Furthermore, levels of CXCL12, VEGF, and BDNF were higher in the plasma and cerebral homogenates of EX rats than sedentary rats and the signaling molecules, ERK and CREB, were also up-regulated in EX rats.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究 (C);  研究期間：2008～2010;   課題番号：20500636;   研究分野：総合領域;   科研費の分科・細目：健康・スポーツ科学 ・応用健康科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60122082"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40122098"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/10512197"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60372645"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60278653"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NIWA, ATSUKO"},{"subitem_text_language":"en","subitem_text_value":"HIGASHINO, HIDEAKI"},{"subitem_text_language":"en","subitem_text_value":"NAKAMURA, KYOKO"},{"subitem_text_language":"en","subitem_text_value":"SAKAUE, HIROSHI"},{"subitem_text_language":"en","subitem_text_value":"OSHIMA, KANA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"徳島大学大学院ヘルスバイオサイエンス研究部; 准教授"},{"subitem_text_value":"近畿大学医学部; 助手"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹羽,  淳子"},{"creatorName":"ニワ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"東野,  英明"},{"creatorName":"ヒガシノ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村,  恭子"},{"creatorName":"ナカムラ, キョウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"阪上,  浩"},{"creatorName":"サカウエ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大島,  佳奈"},{"creatorName":"オオシマ, カナ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20500636seika.pdf","filesize":[{"value":"457.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20500636seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3122/files/KAKEN_20500636seika.pdf"},"version_id":"23422f66-e3e7-4afe-8ccb-8df999c99afb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"運動処方と運動療法","subitem_subject_scheme":"Other"},{"subitem_subject":"脳血管障害","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮前駆細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"血管新生","subitem_subject_scheme":"Other"},{"subitem_subject":"神経新生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"運動習慣は自己修復細胞を活性化しうるか--脳卒中発症遅延と延命効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"運動習慣は自己修復細胞を活性化しうるか--脳卒中発症遅延と延命効果"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3122","relation_version_is_last":true,"title":["運動習慣は自己修復細胞を活性化しうるか--脳卒中発症遅延と延命効果"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:45:58.057996+00:00"}