{"created":"2023-06-20T16:34:02.086279+00:00","id":3115,"links":{},"metadata":{"_buckets":{"deposit":"f81f1e2e-44a5-4c9c-b52d-24cb885f84d8"},"_deposit":{"created_by":3,"id":"3115","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3115"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003115","sets":["14:2667:2689:2693","21:2669:2691:2694"]},"author_link":["3412","3417","3411","3416","3410","3414","3415","3413"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Roles of leukemogenic oncogenes in the regulation of metabolism, growth, and differentiation of hematopoietic stem cells"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： 1. RUNX1のC末端の変異体がGadd45aの発現を抑制してDNA修復能を低下させることを見出した。     2. FIP1L1-PDGFRAが造血幹細胞からの好酸球系前駆細胞’EoP)の発生を増加させるのみでなく、他の系統の前駆細胞からもEoPを産生させることを明らかにした。     3. BCR-ABLおよびその下流のRas/MAPKが骨髄系細胞を増殖させる一方で、p21^<WAF1>を介して赤血球造血を抑制することを見出した。        研究成果の概要（英文）：1.The C-terminal deletion mutant of RUNX1, RUNX1dC, attenuates DNA-damage repair responses to UV irradiation in murine c-KIT^+Sca-1+Lin^- cells by suppressing the expression of Gadd45a.      2. FIP1L1-PDGFRalpha not only enhanced the development of eosinophil progenitors (EoPs) from KSL cells but also aberrantly developed EoPs from progenitors in other lineages.     3.BCR-ABL inhibited erythropoiesis through the induction of p21^<WAF1> via Ras/MAPK, while it promoted granulopoiesis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B);  研究期間：2008～2010;   課題番号：20390269;   研究分野：医歯薬学;   科研費の分科・細目：内科系臨床医学・血液内科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/00294083"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/20177489"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/80283761"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/70324762"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60346202"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"&EMPTY&"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"&EMPTY&"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/90319674"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者(平成21年まで研究分担者として参画）"},{"subitem_text_value":"研究分担者(平成21年まで研究分担者として参画）"},{"subitem_text_value":"研究分担者(平成21年まで研究分担者として参画）"},{"subitem_text_value":"研究分担者(平成21年まで研究分担者として参画）"},{"subitem_text_value":"研究分担者(平成22年から参画）"},{"subitem_text_value":"研究分担者(平成22年から参画）"},{"subitem_text_value":"研究分担者(平成22年から参画）"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUMURA, ITARU"},{"subitem_text_language":"en","subitem_text_value":"KANAKURA, YUZURU"},{"subitem_text_language":"en","subitem_text_value":"MIZUKI, MASAO"},{"subitem_text_language":"en","subitem_text_value":"ORITANI, KENJI"},{"subitem_text_language":"en","subitem_text_value":"SHIBAYAMA, HIROHIKO"},{"subitem_text_language":"en","subitem_text_value":"ASHIDA, TAKASHI"},{"subitem_text_language":"en","subitem_text_value":"TATSUMI, YOICHI"},{"subitem_text_language":"en","subitem_text_value":"SHIMADA, TAKAHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"大阪大学大学院医学系研究科; 教授"},{"subitem_text_value":"大阪大学附属病院; 准教授"},{"subitem_text_value":"大阪大学大学院医学系研究科; 准教授"},{"subitem_text_value":"大阪大学大学院医学系研究科; 講師"},{"subitem_text_value":"近畿大学医学部附属病院; 准教授"},{"subitem_text_value":"近畿大学医学部附属病院; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松村,  到"},{"creatorName":"マツムラ, イタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"金倉,  譲"},{"creatorName":"カナクラ, ユズル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"水木,  満佐央"},{"creatorName":"ミズキ, マサオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"織谷,  健司"},{"creatorName":"オリタニ, ケンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴山,  浩彦"},{"creatorName":"シバヤマ, ヒロヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"芦田,  隆司"},{"creatorName":"アシダ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辰巳,   陽一"},{"creatorName":"タツミ, ヨウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"嶋田,  高広"},{"creatorName":"シマダ, タカヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20390269seika.pdf","filesize":[{"value":"619.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20390269seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3115/files/KAKEN_20390269seika.pdf"},"version_id":"86eb8255-844a-49b1-8e80-88e1a792ed3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"造血幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子変異","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性骨髄性白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"活性型チロシンキナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"増殖シグナル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"造血幹細胞の細胞内代謝・増殖・分化制御と白血病原因遺伝子が及ぼす 影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"造血幹細胞の細胞内代謝・増殖・分化制御と白血病原因遺伝子が及ぼす 影響に関する研究"}]},"item_type_id":"8","owner":"3","path":["2693","2694"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"3115","relation_version_is_last":true,"title":["造血幹細胞の細胞内代謝・増殖・分化制御と白血病原因遺伝子が及ぼす 影響に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:46:12.715270+00:00"}