{"created":"2023-06-20T16:34:01.517066+00:00","id":3103,"links":{},"metadata":{"_buckets":{"deposit":"f1c79715-2106-4c13-862c-871a250a8536"},"_deposit":{"created_by":3,"id":"3103","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3103"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003103","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3284"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of Fra-2 and c-Myb in the oncogenesis of cutaneous T-cell lymphomas"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究において研究代表者は、Fra-2とc-Mybが皮膚T細胞リンパ腫に普遍的に発現し、細胞増殖に関与することを見出した。また、c-MybはFra-2の直接的な標的遺伝子であることが示された。さらに細胞増殖に関わるc-Mybの下流標的遺伝子としてRas活性化因子であるRASGRP2を同定した。Fra-2-c-Myb経路は発癌遺伝子カスケードとして機能し、細胞増殖に寄与することが示唆された。        研究成果の概要（英文）：In this study, we showed that Fra-2 and c-Myb were consistently co-expressed in cutaneous T-cell lymphomas (CTCLs), and contributed to cell proliferation. Furthermore, we showed that c-Myb was a direct target gene of Fra-2 in CTCLs. In addition, we identified that RASGRP2 was a c-Myb target gene and contributed to cell proliferation in CTCLs. Taken together, our findings support the notion that the Fra-2-c-Myb oncogenic pathway plays a major role in the oncogenesis of CTCLs.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;   研究期間：2009～2010;   課題番号：21791103;    研究分野：医歯薬学;    科研費の分科・細目：皮膚科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/60319663"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKAYAMA, TAKASHI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中山,  隆志"},{"creatorName":"ナカヤマ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21791103seika.pdf","filesize":[{"value":"789.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21791103seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3103/files/KAKEN_21791103seika.pdf"},"version_id":"1efc034c-38ab-40f5-b3cb-c221ae847279"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚T細胞リンパ腫","subitem_subject_scheme":"Other"},{"subitem_subject":"Fra-2","subitem_subject_scheme":"Other"},{"subitem_subject":"AP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Myb","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"皮膚T細胞リンパ腫でのFra-2とc-Mybの発癌における役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚T細胞リンパ腫でのFra-2とc-Mybの発癌における役割の解明"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3103","relation_version_is_last":true,"title":["皮膚T細胞リンパ腫でのFra-2とc-Mybの発癌における役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:46:34.355945+00:00"}