{"created":"2023-06-20T16:34:01.390186+00:00","id":3101,"links":{},"metadata":{"_buckets":{"deposit":"24d8e9cf-8dc5-4849-bdcc-a95464956111"},"_deposit":{"created_by":3,"id":"3101","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3101"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003101","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3388"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The analysis of the stress response on glycemic control in liver"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、絶食・再摂食時における肝臓でのホルモンおよびストレス関連因子の遺伝子発現について解析した。その結果、2型糖尿病モデルマウスの肝臓では（１）インスリン様成長因子（IGF-1）発現の低下（２）IGF結合タンパク質-1（IGFBP-1）発現の増強（３）11β-ヒドロキシステロイドデヒドロゲナーゼ（11β-HSD1）の発現亢進（４）ERストレス関連因子の発現低下（５）glucagon-like peptide-1 (GLP-1)の受容体発現の亢進が見出された。        研究成果の概要（英文）：In this study, we analyzed the gene expression of hormone and stress related factors in liver. We found (1) down-expression of insulin-like growth factor-1 (IGF-1), (2, 3) up-expression of IGF binding protein-1 (IGFBP-1) and 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1), (4) the down-expression of ER stress marker and (5) the up-expression of glucagon-like peptide-1 (GLP-1) receptor in liver of type 2 diabetic model mice under the conditions of fasting and refeeding.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究 (B);   研究期間：2009～2010;   課題番号：21790869;    研究分野：医歯薬学;    科研費の分科・細目：内科系臨床医学・代謝学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/10512197"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKAMURA, KYOKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村,  恭子"},{"creatorName":"ナカムラ, キョウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3388","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10512197","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21790869seika.pdf","filesize":[{"value":"474.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21790869seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3101/files/KAKEN_21790869seika.pdf"},"version_id":"465f002d-c226-4e53-a463-23b57f52a734"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"IGFBP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"グルココルチコイド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレス応答による肝臓糖代謝調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレス応答による肝臓糖代謝調節機構の解明"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3101","relation_version_is_last":true,"title":["ストレス応答による肝臓糖代謝調節機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:46:38.093609+00:00"}