{"created":"2023-06-20T16:34:01.330091+00:00","id":3100,"links":{},"metadata":{"_buckets":{"deposit":"026f29e9-71c5-4c94-a0cc-868f850f9a93"},"_deposit":{"created_by":3,"id":"3100","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3100"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003100","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3387"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of rac2 gene expression and its role on anti-HIV-1 restriction"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：HIV-1感染感受性には個人差がある。rac2遺伝子は感染抵抗性遺伝子であり、Rac2の発現が高いヒトはより感染抵抗性になる。本研究ではRac2高発現を制御する１塩基を同定した。また、Rac2の高発現により感染に必須のHIV-1受容体CCR5の発現が減少し、かつ感染阻害活性を持つCCL5の発現が上昇すると分かった。以上からRac2高発現タイプの塩基配列を持つヒトではHIV-1が細胞へ結合しにくくなり感染抵抗性になると考えられる。           研究成果の概要（英文）：Several genetic variations have been identified as factors which affect HIV-1 infection in human. We have recently discovered that human rac2 gene is one of the restriction genes for HIV-1 infection and individuals who possess high-expression type rac2 allele in their genome tend to be more resistant to HIV-1 infection as compared to people with low-expression type rac2 gene allele. During the term of this grant, we identified a single nucleotide polymorphism controlling Rac2 expression in an intron region of the rac2 gene. We found that Rac2 decreases CCR5 expression, a critical co-receptor for HIV-1 infection, at transcriptional level but increases CCL5 which binds to CCR5 and inhibits HIV-1 infection. These results suggest that higher Rac2 expression affects the HIV-1-cell interaction, leading to more resistant against HIV-1 infection.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;   研究期間：2009～2010;   課題番号：21790450;    研究分野：医歯薬学;    科研費の分科・細目：基礎医学・ウイルス学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30344500"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAKATA, YOSHIYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"博多,  義之"},{"creatorName":"ハカタ, ヨシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3387","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30344500","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21790450seika.pdf","filesize":[{"value":"54.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21790450seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3100/files/KAKEN_21790450seika.pdf"},"version_id":"a8350932-351f-43de-abfe-fec9119745f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV-1感染抵抗性遺伝子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Rac2発現の制御機構及びRac2依存的抗HIV-1感染機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rac2発現の制御機構及びRac2依存的抗HIV-1感染機序の解明"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3100","relation_version_is_last":true,"title":["Rac2発現の制御機構及びRac2依存的抗HIV-1感染機序の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:46:40.046740+00:00"}