{"created":"2023-06-20T16:34:01.139495+00:00","id":3097,"links":{},"metadata":{"_buckets":{"deposit":"3e9392d6-9de2-4b02-8cf2-e35185797742"},"_deposit":{"created_by":3,"id":"3097","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3097"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003097","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3385"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Investigation of change of serum glycoproteins with aging and its application to aging marker"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"3","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：生体内の糖鎖は複数の遺伝子産物の協調作業により生合成されるため、細胞の生理的環境の変化を受け容易に変化する。細胞レベルにおけるこれらの微細な変化の蓄積は、老化の過程においても重要な一面を担うと考えられ、種々のバイオマーカー開発の標的としても興味深い。本研究では、抗加齢医学の実践に欠くことのできない加齢マーカーとしての糖鎖の可能性を検証するため、キャピラリー電気泳動（CE）を用いてラット血清糖タンパク質糖鎖の加齢に伴う変化を追跡した。また、メタボリックシンドロームモデル作製用に高脂肪食で飼育したラットの加齢及び食環境の違いが血清糖鎖プロファイルに及ぼす変化を明らかにした。       研究成果の概要（英文）：Since structural alterations of glycans are known to be associated with changes of physiological environments, glycans have been received attention as target molecules for clinical biomarkers. In this study, we analyzed N- and O-glycans of glycoproteins from rat serum samples using capillary electrophoresis, and found that N-glycans showed disitinctive changes with age or high-fat diet. The present results indicate that glycans will be one of the useful biomarkers for aging.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);   研究期間：2009～2010;   課題番号：21790050;    研究分野：医歯薬学;    科研費の分科・細目：薬学・物理系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/40330279"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KINOSHITA, MITSUHIRO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木下,  充弘"},{"creatorName":"キノシタ, ミツヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_21790050seika.pdf","filesize":[{"value":"282.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_21790050seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3097/files/KAKEN_21790050seika.pdf"},"version_id":"c344f359-1a66-4482-be67-98c121181201"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"分析化学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"加齢により変動する血清糖タンパク質糖鎖の解析と加齢マーカーとしての可能性の検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"加齢により変動する血清糖タンパク質糖鎖の解析と加齢マーカーとしての可能性の検証"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3097","relation_version_is_last":true,"title":["加齢により変動する血清糖タンパク質糖鎖の解析と加齢マーカーとしての可能性の検証"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:46:44.939649+00:00"}