{"created":"2023-06-20T16:34:00.585363+00:00","id":3084,"links":{},"metadata":{"_buckets":{"deposit":"eb851fd2-0cd1-485d-90d1-7664e5d7d70b"},"_deposit":{"created_by":3,"id":"3084","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3084"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003084","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3373"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of concentration-sensitive sodium channel in alveolar fluid clearance"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：肺胞上皮に発現している濃度感受性ナトリウムチャネル（NaC）の生理的な機能は分かっていないため、マウス肺における水分調節にNaC が関与しているか検討した。リポ多糖投与により肺に炎症を誘発させると、NaC の発現量が著しく減少した。肺の水分含有量は炎症期に増大し、NaC 発現回復後に減少に転じた。これらの結果は炎症による肺胞上皮のNaC発現の抑制が肺の水分含有量の増大を引き起こしていることを示唆する。  研究成果の概要（英文）：Physiological roles of concentration-sensitive sodium channels (Na_C: c＝concentration) expressed in mouse alveolar epithelial cells are not yet known. In this study, we investigated the role of Na_C in alveolar fluid clearance. Na_C expression dramatically decreased in the lung during inflammation induced by lipopolysaccharide. Lung fluid content increased during early inflammation and decreased after the recovery of Na_C expression.These results suggested that LPS-induced suppression of Na_C in alveolar epithelial cells reduced AFC and caused the increase in lung fluid content in acute lung injury.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;   研究期間：2008～2010;   課題番号：20790183;    研究分野：医歯薬学;    科研費の分科・細目：基礎医学・生理学一般","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/70411577"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAGIWARA, TERUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"萩原,  央記"},{"creatorName":"ハギワラ, テルキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3373","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70411577","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20790183seika.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20790183seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3084/files/KAKEN_20790183seika.pdf"},"version_id":"60af2531-96ea-414d-ab75-7ba1f1015dd0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"ナトリウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"急性肺障害","subitem_subject_scheme":"Other"},{"subitem_subject":"Lung fluid clearance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺水調節における濃度感受性ナトリウムチャネルの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺水調節における濃度感受性ナトリウムチャネルの関与"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3084","relation_version_is_last":true,"title":["肺水調節における濃度感受性ナトリウムチャネルの関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:47:11.468318+00:00"}