{"created":"2023-06-20T16:34:00.540630+00:00","id":3083,"links":{},"metadata":{"_buckets":{"deposit":"6792cdc5-879c-4d90-aa77-dda74db027b6"},"_deposit":{"created_by":3,"id":"3083","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3083"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003083","sets":["14:2667:2689:2690","21:2669:2691:2692"]},"author_link":["3372"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Gonadal function control mechanism in the pituitary gland through long-chain fatty acids as signal molecules."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2010. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究により長鎖脂肪酸がシグナル分子として下垂体の性腺刺激ホルモン産生細胞（ ゴナドトロフ） に直接作用することで長鎖脂肪酸受容体G-protein coupled receptor 120 (GPR120) を活性化すると同時に、性腺刺激ホルモン放出ホルモン受容体 (GnRH-R) 発現を抑制する可能性が示された。また、ゴナドトロフのGPR120 発現はエストロジェンにより制御されていることが明らかとなった。     研究成果の概要（英文）：Present study showed that long-chain fatty acids such as palmitate may directly activate long-chain fatty acid receptor, GPR120, and down-regulate the synthesis of gonadotropin-releasing hormone receptors on gonadotrophs of the mouse pituitary gland as signal molecules. Moreover, it became clear that GPR120 expression levels were controlled by estrogen on the pituitary gland.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);   研究期間：2008～2010;   課題番号：20780202;    研究分野：農学;    科研費の分科・細目：畜産学・獣医学 / 応用動物科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/r/30411573"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MORIYAMA, RYUTARO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森山,  隆太郎"},{"creatorName":"モリヤマ, リュウタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3372","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30411573","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20780202seika.pdf","filesize":[{"value":"705.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20780202seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3083/files/KAKEN_20780202seika.pdf"},"version_id":"29371065-03f8-4231-80c4-7ae4fe55759b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"下垂体","subitem_subject_scheme":"Other"},{"subitem_subject":"性腺刺激ホルモン産生細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪酸","subitem_subject_scheme":"Other"},{"subitem_subject":"低栄養","subitem_subject_scheme":"Other"},{"subitem_subject":"性腺機能","subitem_subject_scheme":"Other"},{"subitem_subject":"GPR120","subitem_subject_scheme":"Other"},{"subitem_subject":"GnRH","subitem_subject_scheme":"Other"},{"subitem_subject":"生殖","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"長鎖脂肪酸をシグナル分子とした下垂体における性腺機能制御メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"長鎖脂肪酸をシグナル分子とした下垂体における性腺機能制御メカニズム"}]},"item_type_id":"8","owner":"3","path":["2690","2692"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-28"},"publish_date":"2011-06-28","publish_status":"0","recid":"3083","relation_version_is_last":true,"title":["長鎖脂肪酸をシグナル分子とした下垂体における性腺機能制御メカニズム"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:47:13.823589+00:00"}