{"created":"2023-06-20T16:34:00.329005+00:00","id":3078,"links":{},"metadata":{"_buckets":{"deposit":"9bf7b1bc-7d6c-4889-a177-0f510081dd6b"},"_deposit":{"created_by":3,"id":"3078","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3078"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003078","sets":["14:2667:2695:2699","21:2669:2697:2700"]},"author_link":["3365"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of a gaseous messenger H2S in cyclophosphamide-induced cystitis and bladder pain"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2009. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究により、シクロホスファミド誘起膀胱炎モデルでは、TRPチャネルを介した初期の炎症が引き金となり、硫化水素合成酵素が発現誘導されることで膀胱内で硫化水素の産生が増大し、これがT型Ca2+チャネルを介して膀胱痛を誘起する一方、炎症症状を悪化させている可能性が示唆された。本知見は、膀胱炎や膀胱痛の治療薬開発において硫化水素合成酵素やT型Ca2+チャネルが新たな標的分子となりうることを強く示唆する。（英文） This study suggests that, in the cyclophosphamide-induced cystitis model, TRP channel-mediated early inflammatory response triggers induction of expression of the hydrogen sulfide synthetic enzyme, leading to increase in the generation of hydrogen sulfide in bladder tissue. The generated hydrogen sulfide induces bladder pain through the T-type Ca2+ channels and aggravates the inflammatory symptom. These findings raise the possibility that hydrogen sulfide synthetic enzyme and/or T-type Ca2+ channels can be new target molecules for the development of therapeutic agents against cystitis and bladder pain.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究 (スタートアップ)研究期間：2008～2009課題番号：20890262研究分野：薬理学科研費の分科・細目：医歯薬学・応用薬理学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000090510123"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUNAMI, MAHO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・薬学部・助手"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松波,  真帆"},{"creatorName":"マツナミ, マホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3365","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90510123","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20890262seika.pdf","filesize":[{"value":"479.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20890262seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3078/files/KAKEN_20890262seika.pdf"},"version_id":"3aac8866-c6a5-42f5-8533-5b981c3e78b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ガスメッセンジャー","subitem_subject_scheme":"Other"},{"subitem_subject":"硫化水素","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱炎","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱痛","subitem_subject_scheme":"Other"},{"subitem_subject":"一次知覚神経","subitem_subject_scheme":"Other"},{"subitem_subject":"神経因性炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"硫化水素合成酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"T型Ca2+チャネル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ガスメッセンジャー硫化水素のシクロホスファミド誘起膀胱炎および膀胱痛への関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ガスメッセンジャー硫化水素のシクロホスファミド誘起膀胱炎および膀胱痛への関与"}]},"item_type_id":"8","owner":"3","path":["2699","2700"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-06"},"publish_date":"2010-07-06","publish_status":"0","recid":"3078","relation_version_is_last":true,"title":["ガスメッセンジャー硫化水素のシクロホスファミド誘起膀胱炎および膀胱痛への関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:47:23.130167+00:00"}