{"created":"2023-06-20T16:34:00.076099+00:00","id":3072,"links":{},"metadata":{"_buckets":{"deposit":"01f934fb-31c1-4b33-a41f-0d63544cbec4"},"_deposit":{"created_by":3,"id":"3072","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3072"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003072","sets":["14:2667:2695:2699","21:2669:2697:2700"]},"author_link":["3355","3354"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Synthesis and evaluation of new α-glucosidase inhibitors having thiosugar-sulfonium salt structure based on salacinol"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2009. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Salacinol (1) は, アーユルベーダ医学で用いられている糖尿病の特効薬物 (Salacia reticulata) から単離された極めて強い血糖値上昇抑制（α-グルコシダーゼ阻害）作用を示す化合物である. 今回, 1 の５員環チオ糖部が阻害活性に及ぼす影響を検討するために, 1 の５員環を開裂した数種のモデル化合物を合成し, その -グルコシダーゼ阻害活性を評価した. その結果, いずれのモデル化合物の活性も極めて低くとどまり, 強い活性発現には 1 の５員環チオ糖構造が必須であることが判明した. （英文） Salacinol (1) is a potent glycosidase inhibitor isolated from Ayurvedic medicine (Salacia reticulata), which is traditionally used for the treatment of diabetes in Sri Lanka and India. In order to determine the effect of 5 membered thiosugar-sulfonium ring structure of 1 on α-glucosidase inhibition, several seco-analogs of 1 were synthesized. Their evaluation as inhibitors indicated that 5 membered ring structure of 1 was essential for the potent inhibition.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（Ｃ）研究期間：2007～2009課題番号：19590111研究分野：医歯薬学科研費の分科・細目：創薬化学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000040217104"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000060088151"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TANABE, GENZO"},{"subitem_text_language":"en","subitem_text_value":"MINEMATSU, TOSHIE"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・薬学部・准教授"},{"subitem_text_value":"近畿大学・薬学部・助手"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田邉,  元三"},{"creatorName":"タナベ, ゲンゾウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"峯松,  敏江"},{"creatorName":"ミネマツ, トシエ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19590111seika.pdf","filesize":[{"value":"403.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19590111seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3072/files/KAKEN_19590111seika.pdf"},"version_id":"13e40d29-82e2-43ff-a8fd-10fe7291523a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-グルコシダーゼ阻害剤","subitem_subject_scheme":"Other"},{"subitem_subject":"サラシノール","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サラシノールをシードとする新規スルホニウム塩型食後過血糖改善剤の合成と活性評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サラシノールをシードとする新規スルホニウム塩型食後過血糖改善剤の合成と活性評価"}]},"item_type_id":"8","owner":"3","path":["2699","2700"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-06"},"publish_date":"2010-07-06","publish_status":"0","recid":"3072","relation_version_is_last":true,"title":["サラシノールをシードとする新規スルホニウム塩型食後過血糖改善剤の合成と活性評価"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:47:34.638723+00:00"}