{"created":"2023-06-20T16:33:59.447227+00:00","id":3057,"links":{},"metadata":{"_buckets":{"deposit":"b460d94d-c953-4715-a561-b9c6e7c6305a"},"_deposit":{"created_by":3,"id":"3057","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3057"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003057","sets":["14:2667:2695:2699","21:2669:2697:2700"]},"author_link":["3320","3318","3322","3319","3321"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study on the pathophysiological role of the Th2-type chemokine receptor CCR4"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2009. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CCR4 はTh2 細胞、制御性T 細胞、皮膚指向性T 細胞などに選択的に発現するケモカイン受容体である。我々はTh2 型のマウス気道炎症で低分子CCR4 阻害剤の治療効果を示した。またCCR4とそのリガンドMDC/CCL22 は腸管膜リンパ節での樹状細胞と制御性T 細胞の相互作用を誘導して免疫寛容を誘導することを示した。さらにEB ウイルスやHTLV-1 といったヒトの腫瘍ウイルスは共通してCCR4 のリガンド、特にMDC/CCL22 の発現を感染細胞に誘導し、それによって感染細胞の周囲にCCR4 陽性のTh2 細胞や制御性T 細胞を動員して免疫回避やウイルス伝播に役立てていることを明らかにした。（英文） CCR4 is a chemokine receptor selectively expressed by Th2 cells, regulatory T cells, and skin-homing T cells. We have shown a potent therapeutic effect of a small molecule CCR4 inhibitor on Th2-induced airway inflammation in mice. We have also shown that CCR4 and its ligand MDC/CCL22 mediate immunosuppressive interactions of dendritic cells and regulatory T cells in mesenteric lymphonodes. Furthermore, human oncogenic viruses such as EBV and HTLV-1 commonly induce expression of MDC/CCL22 in infected host cells to attract Th2 cells and regulatory T cells for immunoevasion and virus propagation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（B）研究期間：2007～2009課題番号：19390277研究分野：医歯薬学科研費の分科・細目：内科系臨床医学・7210","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000010166910"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000010322570"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000060319663"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000010368293"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000030260285"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YOSHIE, OSAMU"},{"subitem_text_language":"en","subitem_text_value":"HIESHIMA, KUNIO"},{"subitem_text_language":"en","subitem_text_value":"NAKAYAMA, TAKASHI"},{"subitem_text_language":"en","subitem_text_value":"NAGAKUBO, DAISUKE"},{"subitem_text_language":"en","subitem_text_value":"SHIRAKAWA, AIKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・医学部・教授"},{"subitem_text_value":"近畿大学医学部・准教授"},{"subitem_text_value":"近畿大学医学部・講師"},{"subitem_text_value":"近畿大学医学部・助教"},{"subitem_text_value":"近畿大学医学部・助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"義江,  修"},{"creatorName":"ヨシエ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"稗島,  州雄"},{"creatorName":"ヒエシマ, クニオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中山,  隆志"},{"creatorName":"ナカヤマ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長久保,  大輔"},{"creatorName":"ナガクボ, ダイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白川,  愛子"},{"creatorName":"シラカワ, アイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19390277seika.pdf","filesize":[{"value":"327.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19390277seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3057/files/KAKEN_19390277seika.pdf"},"version_id":"4c5264dd-daa7-476a-956f-9179654bb237"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CCR4","subitem_subject_scheme":"Other"},{"subitem_subject":"CCL17","subitem_subject_scheme":"Other"},{"subitem_subject":"CCL22","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2","subitem_subject_scheme":"Other"},{"subitem_subject":"Treg","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Ｔｈ２型ケモカイン受容体ＣＣＲ４の生理作用と病的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ｔｈ２型ケモカイン受容体ＣＣＲ４の生理作用と病的役割の解明"}]},"item_type_id":"8","owner":"3","path":["2699","2700"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-06"},"publish_date":"2010-07-06","publish_status":"0","recid":"3057","relation_version_is_last":true,"title":["Ｔｈ２型ケモカイン受容体ＣＣＲ４の生理作用と病的役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:48:02.105174+00:00"}