{"created":"2023-06-20T16:33:59.058930+00:00","id":3048,"links":{},"metadata":{"_buckets":{"deposit":"4a2cd495-dba0-4b83-896e-af8562015443"},"_deposit":{"created_by":3,"id":"3048","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3048"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003048","sets":["14:2667:2695:2696","21:2669:2697:2698"]},"author_link":["3300"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Detection of tumor-derived mutations in circulating DNA"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2009. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EGFR遺伝子変異陽性非小細胞肺癌症例を本研究の対象とした。DNA回収量は血清のほうが多く、ダイレクトシークエンス法よりもScorpion ARMS法の方が、また血清よりも血漿を用いたほうが検出率は高かった。Whole genome amplification(WGA)を用いた検討ではWGAを加えたほうが検出感度は上昇した。問題点として、症例数が不十分であったことが挙げられる。課題として、さらに高感度の検出系の確立が必要である。(英文） Patients with EGFR mutations were enrolled in this study. The concentration of the DNA extracted was higher in the patients’ serum than in their plasma. The rate of EGFR mutation detection was higher, in their DNA from plasma, and by the Scorpion ARMS method. The detection rate was higher when whole genome amplification was performed.A larger study and the establishment of a more sensitive assay is needed to achieve the purpose of this study.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;研究期間：2008 ～ 2009;課題番号：20790565;研究分野：医歯薬学;科研費の分科・細目：内科系臨床医学・呼吸器内科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000040444202"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KIMURA, HIDEHARU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・医学部・講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村,  英晴"},{"creatorName":"キムラ, ヒデハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3300","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40444202","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_20790565seika.pdf","filesize":[{"value":"259.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_20790565seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3048/files/KAKEN_20790565seika.pdf"},"version_id":"c370e947-3617-495b-9e82-17b5552278f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子変異","subitem_subject_scheme":"Other"},{"subitem_subject":"血中DNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血中DNAを用いた腫瘍特異的遺伝子変異の検出とその臨床的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血中DNAを用いた腫瘍特異的遺伝子変異の検出とその臨床的意義"}]},"item_type_id":"8","owner":"3","path":["2696","2698"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-06-30"},"publish_date":"2010-06-30","publish_status":"0","recid":"3048","relation_version_is_last":true,"title":["血中DNAを用いた腫瘍特異的遺伝子変異の検出とその臨床的意義"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:48:17.611938+00:00"}