{"created":"2023-06-20T16:33:57.565353+00:00","id":3020,"links":{},"metadata":{"_buckets":{"deposit":"85221c73-43f5-4e12-ae87-bbf07e70f637"},"_deposit":{"created_by":3,"id":"3020","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3020"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00003020","sets":["14:2667:2701:2702"]},"author_link":["3271","3272"],"control_number":"3020","item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The expression and function of CD133 in cancer cells"}]},"item_8_biblio_info_21":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2008. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がん細胞の幹細胞マーカーCD133 の発現は、mTOR シグナル阻害により発現が誘導され、低酸素およびHIF-1A 誘導剤により発現が著明に抑制されることを見出した。本研究によりCD133 発現制御メカニズムは、HIF-1A を介して抑制的に制御されていることを初めて明らかにした。この研究はがん幹細胞の発生初期のシグナル伝達およびがん幹細胞機能維持の原因解明につながる手がかりになると考えられる。","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;研究期間：2007～2008;課題番号：19790240;研究分野：医歯薬学;科研費の分科・細目：基礎医学：病態医化学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"item_8_description_37","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"item_8_description_41","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"item_8_publisher_14","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000020441074"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000010208134"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ARAO, TOKUZO"},{"subitem_text_language":"en","subitem_text_value":"NISHIO, KAZUTO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・医学部・講師"},{"subitem_text_value":"近畿大学・医学部・教授"}]},"item_8_version_type_12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒尾,  徳三","creatorNameLang":"ja"},{"creatorName":"アラオ, トクゾウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3271","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10208134","nameIdentifierScheme":"研究者番号","nameIdentifierURI":""}]},{"creatorNames":[{"creatorName":"西尾,  和人","creatorNameLang":"ja"},{"creatorName":"ニシオ, カズト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3272","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19790240seika.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19790240seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/3020/files/KAKEN_19790240seika.pdf"},"version_id":"68a3d008-9457-429e-803b-25831a6a84cc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD133","subitem_subject_scheme":"Other"},{"subitem_subject":"がん幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"分子腫瘍学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"幹細胞マーカーCD133の固形癌における発現意義と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"幹細胞マーカーCD133の固形癌における発現意義と機能解析","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"3","path":["2702"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-01-16"},"publish_date":"2010-01-16","publish_status":"0","recid":"3020","relation_version_is_last":true,"title":["幹細胞マーカーCD133の固形癌における発現意義と機能解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-09-27T05:21:52.239848+00:00"}