{"created":"2023-06-20T16:33:56.518309+00:00","id":2996,"links":{},"metadata":{"_buckets":{"deposit":"86e0270b-6792-496e-8e5f-a8ae1354270b"},"_deposit":{"created_by":3,"id":"2996","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2996"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002996","sets":["14:2667:2701:2705","21:2669:2703:2704"]},"author_link":["3219"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Control of genetic expression by conjugate siRNA delocalized in cytoplasm"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2008. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.オリゴDNA/RNAに任意の配列，組成を持つペフ。チドをコンジュゲートすることに成功した。2. オリゴDNAにSV40ラージT抗原由来の核局在化、ングナノレベフOチドをコンジュゲートさせ，ヒト白血病細胞由来の株化細胞に対して細胞内への取り込みを共焦点走査型顕微鏡により観察したところ細胞核へ局在化していることが認められた。3. オリゴDNA-核局在化シグナルコンジュゲートにより，ヒト白血病細胞に発現するテロメラーゼを強く阻害することに成功した。4. オリゴDNAおよびsiRNAにHIV-lrevタンパク由来核外輸送シグ?ナルベフ。チドをコンジュゲートさせ，ヒト白血病細胞由来の株化細胞に対して細胞内への取り込みを共焦点走査型顕微鏡により観察したところ細胞質内へ局在化していることが認められた。","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目:基盤研究(C); 研究期間2006～2008; 課題番号18550158; 研究分野:化学; 科研費の分科・細目:複合化学・生体関連化学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000060199297"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FUJII, MASAYUKI"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・産業理工学部・教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤井,  政幸"},{"creatorName":"フジイ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3219","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60199297","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_18550158seika.pdf","filesize":[{"value":"224.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_18550158seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2996/files/KAKEN_18550158seika.pdf"},"version_id":"9de2635c-b20b-482d-a9c4-9369d4c46f72"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"核酸","subitem_subject_scheme":"Other"},{"subitem_subject":"蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"糖化学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞質局在化コンジュゲートsiRNAによる遺伝子発現制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞質局在化コンジュゲートsiRNAによる遺伝子発現制御"}]},"item_type_id":"8","owner":"3","path":["2704","2705"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-18"},"publish_date":"2010-01-18","publish_status":"0","recid":"2996","relation_version_is_last":true,"title":["細胞質局在化コンジュゲートsiRNAによる遺伝子発現制御"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:49:53.659687+00:00"}