{"created":"2023-06-20T16:33:55.799379+00:00","id":2981,"links":{},"metadata":{"_buckets":{"deposit":"aefb14f0-58ae-4ea9-8db7-bfccc0e43872"},"_deposit":{"created_by":3,"id":"2981","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2981"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002981","sets":["14:2667:2701:2705","21:2669:2703:2704"]},"author_link":["3179","3178"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A novel therapeutic approach to central nervous system demyelinating disease with anti-platelet agents"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費補助金研究成果報告書 (2008. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗血小板薬であるCilostazol が多発性硬化症の動物モデルである実験的自己免疫性脳脊髄炎（EAE）の治療に有効であることを見出した。MOG 誘導マウスEAE にCilostazol 含有エサを継続投与するとEAE 症状は有意に軽症化した。MOG 反応性T 細胞のrecall response はCilostazol 投与群では増殖反応やIFNγ産生が抑制され、血清中の可溶性接着分子であるICAM-1 やp-selectin が有意に低下した。以上より、Cilostazol は自己反応性T 細胞増殖や接着分子の発現を抑制することによりEAE に対する治療効果を有する。","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）; 研究期間：2007〜2008; 課題番号： 19591018; 研究分野：医歯薬学; 科研費の分科・細目：内科系臨床医学・神経内科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000050388526"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://rns.nii.ac.jp/nr/1000090195438"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MIYAMOTO, KATSUICHI"},{"subitem_text_language":"en","subitem_text_value":"KUSUNOKI, SUSUMU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・医学部・講師"},{"subitem_text_value":"近畿大学・医学部・教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮本,  勝一"},{"creatorName":"ミヤトモ, カツイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"楠,  進"},{"creatorName":"クスノキ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"KAKEN_19591018seika.pdf","filesize":[{"value":"229.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_19591018seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2981/files/KAKEN_19591018seika.pdf"},"version_id":"ca3e0dba-4a0a-474d-b359-50e7c3a83ae4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経内科","subitem_subject_scheme":"Other"},{"subitem_subject":"神経免疫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"中枢神経脱髄疾患に対する抗血小板薬を用いた新規治療法開発の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢神経脱髄疾患に対する抗血小板薬を用いた新規治療法開発の研究"}]},"item_type_id":"8","owner":"3","path":["2704","2705"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-18"},"publish_date":"2010-01-18","publish_status":"0","recid":"2981","relation_version_is_last":true,"title":["中枢神経脱髄疾患に対する抗血小板薬を用いた新規治療法開発の研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:50:28.430226+00:00"}