{"created":"2023-06-20T16:33:55.190180+00:00","id":2968,"links":{},"metadata":{"_buckets":{"deposit":"2117d105-7384-4063-94bc-aa49aac47fe2"},"_deposit":{"created_by":3,"id":"2968","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2968"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002968","sets":["14:2667:2668","21:2669:2670"]},"author_link":["3145","3144","3143"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Functional analysis of LPA receptors in the acquisition of malignant properties in cancer cells."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): リゾフォスファチジン酸(LPA)は生理活性物質のひとつで, 7回膜貫通型Gタンパク共役受容体であるLPA受容体(LPA1－LPA6)に結合することで様々な細胞応答を制御する. 本研究は, がんの浸潤・転移, 造腫瘍性, 血管新生、抗がん剤耐性などがんの増悪化に6種類のLPA受容体がどのような役割を演じるかを検索した. その結果, LPA受容体はがん細胞の種類によって発現レベルが異なることと, がん細胞特異的にがんの増悪化を促進または抑制することが明らかとなった. 本研究成果より, LPA受容体を介するLPAシグナル伝達経路が新規分子標的療法の標的候補分子となりうる可能性が示唆された.             研究成果の概要（英文): Lysophosphatidic acid (LPA) is one of extracellular physiological lipids and interacts with G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). LPA receptors regulate a variety of biological functions through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. In this study, to assess an involvement of LPA receptors in the acquisition of malignant potency, we generated LPA receptor knockdown cells and measured cell motile and invasive activities, tumorigenicity and angiogenic activity of cancer cells. The present results demonstrate that each LPA receptor acts as a positive or negative regulator of tumor progression, dependent on types of cancer cells. Therefore, it is suggested that LPA signaling via LPA receptors may be a target molecule for the establishment of chemoprevention agents in clinical cancer therapy.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24590493;   研究分野：分子腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/30434856.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/40336863.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10254161.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TSUJIUCHI, Toshifumi"},{"subitem_text_language":"en","subitem_text_value":"HONOKI, Kanya"},{"subitem_text_language":"en","subitem_text_value":"FUKUSHIMA, Nobuyuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 教授"},{"subitem_text_value":"奈良県立医科大学医学部; 講師"},{"subitem_text_value":"近畿大学理工学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Nara Medical University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻内,  俊文"},{"creatorName":"ツジウチ, トシフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"朴木,  寛弥"},{"creatorName":"ホノキ, カンヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福嶋,  伸之"},{"creatorName":"フクシマ, ノブユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24590493seika.pdf","filesize":[{"value":"138.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24590493seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2968/files/24590493seika.pdf"},"version_id":"8a0c13c0-11ee-4135-a120-913bbdf71b84"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LPA受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"がん浸潤","subitem_subject_scheme":"Other"},{"subitem_subject":"がん転移","subitem_subject_scheme":"Other"},{"subitem_subject":"抗がん剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"血管新生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がんの増悪化におけるＬＰＡ受容体機能の解析と臨床応用にむけた標的分子の探究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がんの増悪化におけるＬＰＡ受容体機能の解析と臨床応用にむけた標的分子の探究"}]},"item_type_id":"8","owner":"3","path":["2668","2670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"2968","relation_version_is_last":true,"title":["がんの増悪化におけるＬＰＡ受容体機能の解析と臨床応用にむけた標的分子の探究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:50:55.460811+00:00"}