{"created":"2023-06-20T16:33:55.063955+00:00","id":2965,"links":{},"metadata":{"_buckets":{"deposit":"f0d02242-9a70-4912-8e0c-3a6379ac241e"},"_deposit":{"created_by":3,"id":"2965","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2965"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002965","sets":["14:2667:2668","21:2669:2670"]},"author_link":["3137","3138"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Abnormal LPA receptor signaling in cancer"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): リゾホスファチジン酸（LPA）は多様な生理活性を示す脂質メディエーターであり、その作用はLPA受容体（LPA1～LPA6）を介して生じる. これまでLPAシグナルががん発生・増殖・進展に関与していることが示唆されており, がん治療の新規標的と考えられている. 本研究では, がん組織で発現している,  LPAの作用を検討したところ, LPAシグナルの結果と思われていたがん細胞に対する作用の一部が, その構成成分である脂肪酸に由来するという, 新たな知見を得た.             研究成果の概要（英文): Lysophosphatidic acid (LPA) is a lysolipid mediator that exerts various physiological actions. The effects of LPA are mediated through at least six types of LPA receptors, including LPA1~LPA6. Involvement of LPA receptor-mediated signaling in cancer growth has been so far suggested. The present study demonstrated that LPA receptor mutants observed in cancer tissues showed abnormal cellular distribution and intracellular signaling. Further analysis for LPA signaling in a certain type of ovarian cancer cell line revealed that the effects of LPA signaling were partly attributed to a fatty acid liberated from LPA.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B);  研究期間：2012～2014;   課題番号：24590129;   研究分野：細胞生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10254161.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10254492.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FUKUSHIMA, Nobuyuki"},{"subitem_text_language":"en","subitem_text_value":"TSUJIUCHI, Toshifumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 准教授"},{"subitem_text_value":"近畿大学理工学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福嶋,  伸之"},{"creatorName":"フクシマ, ノブユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"辻内,  俊文"},{"creatorName":"ツジウチ, トシフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24590129seika.pdf","filesize":[{"value":"210.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24590129seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2965/files/24590129seika.pdf"},"version_id":"3c37f57a-a163-41d0-908b-fd693781c2c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リゾホスファチジン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"変異体","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪酸","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"リゾホスファチジン酸受容体のシグナル異常とがん","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リゾホスファチジン酸受容体のシグナル異常とがん"}]},"item_type_id":"8","owner":"3","path":["2668","2670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"2965","relation_version_is_last":true,"title":["リゾホスファチジン酸受容体のシグナル異常とがん"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:51:02.016338+00:00"}