{"created":"2023-06-20T16:33:55.021658+00:00","id":2964,"links":{},"metadata":{"_buckets":{"deposit":"baf744b4-3d8e-4d35-a401-a6d31a48e66b"},"_deposit":{"created_by":3,"id":"2964","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2964"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002964","sets":["14:2667:2668","21:2669:2670"]},"author_link":["3135","3136"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Search for new metabolic syndrome therapeutic candidates from Thai natural medicines"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 熱帯から亜熱帯に位置し, 薬用資源の世界的に豊富なタイ地域の薬用植物資源のうち, タイ伝統医薬学に用いられ, かつ, 食経験があるなど安全性が確立している素材について厳選し, メタボリックシンドロームに対する予防効果を有する新規医薬シーズの探索研究を実施した. その結果, I. 小腸からの糖および中性脂質吸収抑制作用, II. ラットおよびヒト小腸由来 α-グルコシダーゼ阻害作用, III. リポ多糖刺激によるマクロファージ活性化抑制作用, およびiv. ヒト肝がん由来HepG2細胞を用いた中性脂質代謝促進作用を有するタイ天然薬物を見いだすともに, その活性寄与成分および構造活性相関に関する知見を得た.          研究成果の概要（英文): To investigate prevention and/or treatment for metabolic syndrome therapeutic candidates from Thai natural medicines, we examined following in vivo and in vitro pharmacological assays such as (I) suppressive effects on blood glucose and triglyceride elevation in sugar or olive oil-loaded mice, (II) inhibitory effects on rat or human small intestinal α-glucosidases, (III) suppressive effects on nitric oxide production in lipopolysaccharide-activated macrophages, and (IV) inhibitory effects on triglyceride content in high glucose-pretreated HepG2 cells, etc. As the results, several constituents were identified as the active compounds and their structural requirements and the mode of action were suggested.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24590037;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10340449.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10434862.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MORIKAWA, Toshio"},{"subitem_text_language":"en","subitem_text_value":"NINOMIYA, Kiyofumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学総合研究所; 准教授"},{"subitem_text_value":"近畿大学薬学総合研究所; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森川,  敏生"},{"creatorName":"モリカワ, トシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3135","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10434862","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"二宮,  清文"},{"creatorName":"ニノミヤ, キヨフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3136","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24590037seika.pdf","filesize":[{"value":"591.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24590037seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2964/files/24590037seika.pdf"},"version_id":"5df90aac-ab5e-478c-bf1d-fde299078574"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"タイ天然薬物","subitem_subject_scheme":"Other"},{"subitem_subject":"メタボリックシンドローム","subitem_subject_scheme":"Other"},{"subitem_subject":"シーズ探索","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"タイ天然薬物を素材としたメタボリックシンドローム予防および治療薬シーズの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"タイ天然薬物を素材としたメタボリックシンドローム予防および治療薬シーズの探索"}]},"item_type_id":"8","owner":"3","path":["2668","2670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"2964","relation_version_is_last":true,"title":["タイ天然薬物を素材としたメタボリックシンドローム予防および治療薬シーズの探索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:51:04.249790+00:00"}