{"created":"2023-06-20T16:33:54.769341+00:00","id":2958,"links":{},"metadata":{"_buckets":{"deposit":"bfa03ad1-c09e-4f1c-8c26-420864bd79e8"},"_deposit":{"created_by":3,"id":"2958","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2958"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002958","sets":["14:2667:2668","21:2669:2670"]},"author_link":["3128"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Ophthalmic formulation of solid nanoparticles permits the retinal therapy, and lead to the therapy in the glaucoma patient"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 申請者らは医薬品ナノ結晶の新規調製法の確立を目的とし, シロスタゾール（CLZ）を含む高品質のナノ粒子含有分散液（CLZナノ結晶点眼液）の調製に成功した. また, これらCLZナノ結晶点眼液点眼は, エンドセリン-1硝子体注射によるラット網膜血管収縮を抑制することを明らかとした. 以上, シロスタゾールナノ結晶含有点眼液の調製方法を確立するとともに, 本点眼液が緑内障治療に有用である可能性を示した.                     研究成果の概要（英文): We attempted to establish a new method for preparing drug solid nanoparticles, and succeeded in preparing a high quality dispersion containing cilostazol (CLZ) nanoparticles. In addition, the instillation of the ophthalmic dispersions containing CLZ nanoparticles suppresses retinal vasoconstriction in endothelin-1-injected rats. It is possible that an ocular drug delivery system using drug nanoparticles may expand their usage as therapy in the glaucoma patient.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2013～2014;   課題番号：25860129;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90411579.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAGAI, Noriaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長井,  紀章"},{"creatorName":"ナガイ, ノリアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"25860129seika.pdf","filesize":[{"value":"199.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25860129seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2958/files/25860129seika.pdf"},"version_id":"0e43f564-cc7f-4de6-8d88-436e789b2191"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ナノ粒子","subitem_subject_scheme":"Other"},{"subitem_subject":"シロスタゾール","subitem_subject_scheme":"Other"},{"subitem_subject":"眼後部治療","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜","subitem_subject_scheme":"Other"},{"subitem_subject":"緑内障","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜透過","subitem_subject_scheme":"Other"},{"subitem_subject":"眼圧","subitem_subject_scheme":"Other"},{"subitem_subject":"DDS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ナノ化技術を用いた点眼による網膜療法の確立と緑内障治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ナノ化技術を用いた点眼による網膜療法の確立と緑内障治療への応用"}]},"item_type_id":"8","owner":"3","path":["2668","2670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"2958","relation_version_is_last":true,"title":["ナノ化技術を用いた点眼による網膜療法の確立と緑内障治療への応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:51:15.316830+00:00"}