{"created":"2023-06-20T16:33:54.139930+00:00","id":2943,"links":{},"metadata":{"_buckets":{"deposit":"c113875f-05c8-491d-b748-9d13003d1bb2"},"_deposit":{"created_by":3,"id":"2943","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2943"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002943","sets":["14:2667:2668","21:2669:2670"]},"author_link":["3107"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Application of inhibitory method of pancreatic cancer cell growth by the regulation of lumican glycosylation using therapeutic peptides."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2014. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): ルミカンの発現量と細胞増殖能には正の相関性があり, 細胞浸潤能とは負の相関性があることが報告されている. 今回, ルミカンが膵癌細胞の増殖や浸潤に関わる機構について検討するため, ルミカン発現調製細胞を用い, それらの細胞の発現タンパク質の変動を網羅的に解析した. その結果, 24種類のタンパク質がルミカンの発現と相関性があることが明らかとなった. この中にはアポトーシスのマーカーとして知られているタンパク質やMMP-9の活性化と関連があるタンパク質が含まれていたことから、ルミカンはアポトーシスやこれらのタンパク質の発現に関わることで細胞増殖や浸潤を制御していると考えられた.                研究成果の概要（英文): It has been reported that lumican expression level showed positive correlation with cell growth of pancreatic ductal adenocarcinoma (PDAC) cells and showed negative correlation with cell invasion of PDAC cells. In this study, we performed global shotgun proteomic analysis using lumican-regulated PANC-1 cells to examine the effect of lumican on cell growth and invasion in PDAC cells. As a result of proteomics, 24 proteins were identified as candidate proteins which expression was regulated by lumican, and these candidate proteins included protein which is known apoptosis marker and protein which regulate MMP-9 activation. Thus, lumican might be involved in cell growth and invasion to regulate cell apoptosis and these proteins expression.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2014;   課題番号：24591019;   研究分野：医歯薬科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/10254161.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YAMAMOTO, Tetsushi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本,  哲志"},{"creatorName":"ヤマモト, テツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3107","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20453920","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"24591019seika.pdf","filesize":[{"value":"86.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24591019seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/2943/files/24591019seika.pdf"},"version_id":"223c2429-9cb2-41f6-b52c-63ab420d6851"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"膵臓癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ルミカン","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオグリカン","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオミクス","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ペプチド製剤を用いたルミカンの特異糖鎖修飾制御による膵癌細胞増殖抑制法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ペプチド製剤を用いたルミカンの特異糖鎖修飾制御による膵癌細胞増殖抑制法の開発"}]},"item_type_id":"8","owner":"3","path":["2668","2670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-19"},"publish_date":"2015-11-19","publish_status":"0","recid":"2943","relation_version_is_last":true,"title":["ペプチド製剤を用いたルミカンの特異糖鎖修飾制御による膵癌細胞増殖抑制法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T01:51:46.139295+00:00"}