{"created":"2023-06-20T16:50:54.141836+00:00","id":23518,"links":{},"metadata":{"_buckets":{"deposit":"38592e52-44eb-4b4f-b420-988184da5a6f"},"_deposit":{"created_by":3,"id":"23518","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23518"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023518","sets":["14:923:1477:4830"]},"author_link":["43589","43591","43590"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"176","bibliographicPageStart":"165","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] 肺静脈由来の異所性興奮が発作性心房細動 (paroxysmal atrial fibrillation : PAF) の発症に関わることが報告されている．さらに最近では肺静脈はPAFの発症にのみ関与するのではなく，PAFを維持させる基質 (substrate) としても重要な役割を果たすことが示唆されている．肺静脈の電気生理学的特性はその構造の多様さから，興奮伝導の異方向性様式に言及したものが主であり，自律神経系への肺静脈の関与はほとんど明らかにされていない．そこで我々はPAFの既往をもつ患者ともたない患者において，交感神経刺激薬であるイソプロテレノール (isoproterenol : ISP) に対する肺静脈の反応性の相違を検討した．PAF患者10例 (PAF群) と非PAF患者10例 (control 群) に対し電気生理学的検査を施行．両上肺静脈 (left superior pulmonary vein : LSPVと right superior pulmonary vein : RSPV) 及び左心房 (left atrium : LA) の有効不応期 (effective refractory period : ERP) 及び肺静脈-左房間の伝導時間を無投薬下とISP投与下にて測定した．無投薬下において，control 群，PAF群共に各部位でERPに有意な短縮を認めなかった．ISP投与下において，肺静脈のERPはPAF群にてLAのERPと比し有意に短縮していたが (LSPV : 120±58，RSPV : 158±32 versus LA : 191±22 ms，それぞれp<0.01，p<0.05)，control 群では認めなかった．control 群とPAF群のERPの比較では，無投薬下では両上肺静脈のERPに有意な短縮を認めなかったが，ISP投与下では，PAF群の肺静脈で有意にERPの短縮を認めた (LSPV : 194±27 versus 120±58 ms，p<0.01 ; RSPV : 205±14 versus 158±32 ms，p<0.001)．肺静脈-左房間伝導時間はISP投与後に，最短の期外刺激時の伝導時間において，PAF群で有意に延長していた (LSPV : 125±24 versus 209±67 ms，p<0.01 ; RSPV : 106±26 versus 164±70 ms，p<0.05)．PAFの患者では，両上肺静脈におけるISPに対する感受性の亢進が示唆された．PAF患者におけるISP投与後の肺静脈内のERPの短縮と伝導時間の延長は，micro reentry の形成を容易とし，肺静脈の不整脈源性を増強するものであり，PAFの維持に重要な役割を果たすと考えられた。","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部内科学教室(循環器内科部門)"},{"subitem_text_value":"近畿大学医学部内科学教室(循環器内科部門)"},{"subitem_text_value":"近畿大学医学部内科学教室(循環器内科部門)"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"},{"subitem_text_value":"Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"元木, 康一郎"}],"nameIdentifiers":[{"nameIdentifier":"43589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井, 博之"}],"nameIdentifiers":[{"nameIdentifier":"43590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川, 欽司"}],"nameIdentifiers":[{"nameIdentifier":"43591","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-07"}],"displaytype":"detail","filename":"AN00063584-20041225-0165.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20041225-0165.pdf","url":"https://kindai.repo.nii.ac.jp/record/23518/files/AN00063584-20041225-0165.pdf"},"version_id":"a773c59d-d2a2-4ad6-81c2-add94c2268ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"発作性心房細動","subitem_subject_scheme":"Other"},{"subitem_subject":"肺静脈","subitem_subject_scheme":"Other"},{"subitem_subject":"有効不応期","subitem_subject_scheme":"Other"},{"subitem_subject":"イソプロテレノール","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉発作性心房細動患者における肺静脈のイソプロテレノールに対する反応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉発作性心房細動患者における肺静脈のイソプロテレノールに対する反応"}]},"item_type_id":"2","owner":"3","path":["4830"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-07"},"publish_date":"2022-12-07","publish_status":"0","recid":"23518","relation_version_is_last":true,"title":["〈原著〉発作性心房細動患者における肺静脈のイソプロテレノールに対する反応"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:39:24.630640+00:00"}